2026-05-17T01:18:37Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/270912025-12-19T01:16:41Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Zuriaga, María A
author
Fuster, José J
funder
Instituto de Salud Carlos III
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Fundación La Marató TV3
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2025-12-18T09:32:59Z
2025-12-18T09:32:59Z
2025-05
Diabetologia. 2025 May;68(5):920-929.
DIABETOLOGIA
40064675
https://hdl.handle.net/20.500.12105/27091
The accumulation of acquired somatic mutations is a natural consequence of ageing, but the pathophysiological implications of these mutations beyond cancer are only beginning to be understood. Most somatic mutations are functionally neutral, but a few may confer a competitive advantage to a stem cell, driving its clonal expansion. When such a mutation arises in haematopoietic stem cells, it leads to clonal haematopoiesis, in which a significant proportion of blood cells originate from the mutant stem cell and share the same mutation. Clonal haematopoiesis of indeterminate potential (CHIP), a specific subset of clonal haematopoiesis driven by myeloid leukaemia-related somatic mutations, has been linked to a higher risk of various age-related conditions, particularly CVD, by exacerbating inflammatory responses. Emerging evidence suggests that CHIP may also contribute to the pathogenesis of type 2 diabetes and some of its complications. This review synthesises current knowledge on CHIP and its potential as a novel risk factor for type 2 diabetes, highlighting the need for further research to clarify this relationship and to explore its potential value in developing personalised preventive care strategies for type 2 diabetes and related conditions.
eng
DNMT3A
TET2
CHIP
Cardiovascular disease
Diabetes
Inflammation
Insulin resistance
Kidney disease
Review
Somatic mutation
Clonal haematopoiesis of indeterminate potential: an emerging risk factor for type 2 diabetes and related complications.
review
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URL
https://repisalud.isciii.es/bitstreams/e8ed1037-ed7d-488b-9fa3-9e90b886e403/download
File
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2b4c9a835d87f746d6222855b1d378b6
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application/pdf
Clonal haematopoiesis of indeterminate potential_Diabetologia_2025.pdf