2026-05-14T15:11:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/270612025-12-18T12:57:50Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Welt, Frederick G P
author
Batchelor, Wayne
author
Spears, J Richard
author
Penna, Claudia
author
Pagliaro, Pasquale
author
Ibanez, Borja
author
Drakos, Stavros G
author
Dangas, George
author
Kapur, Navin K
2025-12-16T16:54:30Z
2025-12-16T16:54:30Z
2024-06-04
J Am Coll Cardiol. 2024 Jun 4;83(22):2196-2213.
Journal of the American College of Cardiology
38811097
https://hdl.handle.net/20.500.12105/27061
Despite impressive improvements in the care of patients with ST-segment elevation myocardial infarction, mortality remains high. Reperfusion is necessary for myocardial salvage, but the abrupt return of flow sets off a cascade of injurious processes that can lead to further necrosis. This has been termed myocardial ischemia-reperfusion injury and is the subject of this review. The pathologic and molecular bases for myocardial ischemia-reperfusion injury are increasingly understood and include injury from reactive oxygen species, inflammation, calcium overload, endothelial dysfunction, and impaired microvascular flow. A variety of pharmacologic strategies have been developed that have worked well in preclinical models and some have shown promise in the clinical setting. In addition, there are newer mechanical approaches including mechanical unloading of the heart prior to reperfusion that are in current clinical trials.
eng
STEMI
inflammation
ischemia
reperfusion
Reperfusion Injury in Patients With Acute Myocardial Infarction: JACC Scientific Statement.
review article
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URL
https://repisalud.isciii.es/bitstreams/00e9f406-3a6b-4166-9b2e-acf89232b9d3/download
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d4e4b284cd34e7abbeb185a43aa8d60c
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Reperfusion Injury in Patients With Acute_J Am Coll Cardiol_2024.pdf