2026-05-14T15:11:46Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/270612025-12-18T12:57:50Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587

00925njm 22002777a 4500 dc Welt, Frederick G P author Batchelor, Wayne author Spears, J Richard author Penna, Claudia author Pagliaro, Pasquale author Ibanez, Borja author Drakos, Stavros G author Dangas, George author Kapur, Navin K author 2024-06-04 Despite impressive improvements in the care of patients with ST-segment elevation myocardial infarction, mortality remains high. Reperfusion is necessary for myocardial salvage, but the abrupt return of flow sets off a cascade of injurious processes that can lead to further necrosis. This has been termed myocardial ischemia-reperfusion injury and is the subject of this review. The pathologic and molecular bases for myocardial ischemia-reperfusion injury are increasingly understood and include injury from reactive oxygen species, inflammation, calcium overload, endothelial dysfunction, and impaired microvascular flow. A variety of pharmacologic strategies have been developed that have worked well in preclinical models and some have shown promise in the clinical setting. In addition, there are newer mechanical approaches including mechanical unloading of the heart prior to reperfusion that are in current clinical trials. J Am Coll Cardiol. 2024 Jun 4;83(22):2196-2213. Journal of the American College of Cardiology 38811097 https://hdl.handle.net/20.500.12105/27061 STEMI inflammation ischemia reperfusion Reperfusion Injury in Patients With Acute Myocardial Infarction: JACC Scientific Statement.