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oai:repisalud.isciii.es:20.500.12105/270602025-12-18T12:57:36Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Nielsen, Rikke V author Fuster, Valentin author Bundgaard, Henning author Fuster, Jose J author Johri, Amer M author Kofoed, Klaus F author Douglas, Pamela S author Diederichsen, Axel author Shapiro, Michael D author Nicholls, Stephen J author Nordestgaard, Børge G author Lindholt, Jes S author MacRae, Calum author Yuan, Chun author Newby, David E author Urbina, Elaine M author Bergström, Göran author Ridderstråle, Martin author Budoff, Matthew J author Bøttcher, Morten author Raitakari, Olli T author Hansen, Thomas H author Näslund, Ulf author Sillesen, Henrik author Eldrup, Nikolaj author Ibanez, Borja author 2024-05-28 Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide and challenges the capacity of health care systems globally. Atherosclerosis is the underlying pathophysiological entity in two-thirds of patients with CVD. When considering that atherosclerosis develops over decades, there is potentially great opportunity for prevention of associated events such as myocardial infarction and stroke. Subclinical atherosclerosis has been identified in its early stages in young individuals; however, there is no consensus on how to prevent progression to symptomatic disease. Given the growing burden of CVD, a paradigm shift is required-moving from late management of atherosclerotic CVD to earlier detection during the subclinical phase with the goal of potential cure or prevention of events. Studies must focus on how precision medicine using imaging and circulating biomarkers may identify atherosclerosis earlier and determine whether such a paradigm shift would lead to overall cost savings for global health. J Am Coll Cardiol. 2024 May 28;83(21):2112-2127. https://hdl.handle.net/20.500.12105/27060 38777513 Journal of the American College of Cardiology atherosclerosis cardiovascular disease imaging precision medicine primary prevention Personalized Intervention Based on Early Detection of Atherosclerosis: JACC State-of-the-Art Review.