2026-05-17T00:20:32Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/270582025-12-18T12:57:36Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc He, Chenfei author Wang, Shan author Moreews, Marion author Pei, Shengduo author Chen, Guangchun author Li, Quan-Zhen author Del Monte Monge, Alberto author Ramiro, Almudena R author Cai, Curtis author Gaya, Mauro author Barral, Patricia author Buggert, Marcus author Batista, Facundo D author Karlsson, Mikael C I author 2025-05-27 Invariant natural killer T (iNKT) cells are activated by glycolipids presented on CD1d. When iNKT cells interact with and activate B cells, they can differentiate into iNKT follicular helper (iNKTfh) cells, and here, we investigate how this, in turn, regulates conventional T follicular helper (Tfh) cells. This is done in an autoimmune model where antibodies are produced against self-antigens relevant to the autoimmune disease systemic lupus erythematosus (SLE). We find a balance between iNKTfh and Tfh cells that directs the B cell response and influences Tfh cell generation. This altered balance also affects the specificities and increases the autoantibody response. We also show that CD1d expression by B cells is essential for iNKTfh cell generation. In conclusion, our data shed light on how T cell help for B cells is divided between conventional and unconventional helper cell populations and how this has an impact on autoreactive B cell responses. Cell Rep. 2025 May 27;44(5):115602. CELL REPORTS 40252220 https://hdl.handle.net/20.500.12105/27058 CD1d CP: Immunology T follicular helper cells apoptotic cells autoimmune disease germinal center The balance between conventional and unconventional T follicular helper cells influences autoreactive B cell responses.