2026-05-21T23:03:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/270252025-12-18T13:01:57Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Barrero-Gil, Javier
author
Mouriz, Alfonso
author
Piqueras, Raquel
author
Tian, Yingnan
author
López, Juan A
author
Vázquez, Jesús
author
Crevillén, Pedro
author
Jarillo, José A
author
Piñeiro, Manuel
funder
Comunidad de Madrid (España)
funder
Fundación La Caixa
funder
Ministerio de Educación (España)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
2025-12-15T14:11:29Z
2025-12-15T14:11:29Z
2025-10-31
Plant Physiol. 2025 Oct 31;199(3):kiaf511.
PLANT PHYSIOLOGY
41100683
https://hdl.handle.net/20.500.12105/27025
INHIBITOR OF GROWTH (ING) proteins are chromatin readers that bind trimethylated histone H3 lysine (K) 4 (H3K4me3) marks and associate with either histone acetyltransferase or deacetylase complexes to activate or repress gene transcription, respectively. In plants, there are two types of ING proteins, namely ING1 and ING2. Here, we report that Arabidopsis thaliana ING2 associates with multiple subunits of the histone H4 acetyltransferase complex NuA4, controls genome-wide levels of histone H4 acetylation (H4ac), and regulates different developmental processes, including the initiation of flowering. Our data indicate that ING2 biological functions are largely independent of ING1 activity. We find that ING2 is recruited to the chromatin of key floral integrators, such as FT and SOC1, and is required for their timely activation by modulating histone H4ac levels at these loci. Our observations reveal a genetic interaction between ING2 and genes encoding relevant proteins for H3K4me3 or H2A.Z deposition, suggesting that ING2 might represent a hub for potential crosstalk between histone H4ac and these histone modifications/variants.
eng
Arabidopsis INHIBITOR OF GROWTH 2 promotes flowering by regulating NuA4-dependent H4 acetylation levels at FT and SOC1.
research article
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URL
https://repisalud.isciii.es/bitstreams/92685d1e-0da5-40d3-95ea-eddf58b04fd0/download
File
MD5
4321982e4da6957bfe2632ee51996265
10997486
application/pdf
Arabidopsis INHIBITOR OF GROWTH_Plant Physiol_2025.pdf