2026-06-14T02:27:55Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/270172025-12-13T01:19:53Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19612

00925njm 22002777a 4500 dc Linertová, Renata author Guirado-Fuentes, Carmen author Mar Medina, Javier author Imaz-Iglesia, Iñaki author Rodríguez-Rodríguez, Leticia author Carmona, Montserrat author 2021-09 Background: Human papillomavirus (HPV) infection can have severe consequences both in women and men. Preadolescent girls are vaccinated against HPV worldwide but a gender-neutral vaccination is being adopted only little by little. This systematic review offers an overview of cost-effectiveness of the gender-neutral HPV vaccination. Methods: Economic evaluations of gender-neutral HPV vaccination with a two-dose schedule compared with girls-only strategy were systematically searched in Medline, Embase and WOS up to June 2020. Incremental cost-effectiveness ratios and key parameters were analysed. Results: Nine studies met the inclusion criteria. Four studies concluded in favour of the gender-neutral programme, another four found it cost-effective only in alternative scenarios. The most influential parameters are the discount rate of benefits (same as for costs vs reduced), vaccine price (listed vs publicly negotiated) and included health problems (inclusion of oropharyngeal and penile cancers). Sponsorship was not decisive for the final result, but there were differences between industry-funded and independent studies in some cost categories. Conclusions: The evidence of the cost-effectiveness of extending HPV vaccination to boys is scarce and ambiguous. Before the adoption of such a strategy, countries should carry out context-specific cost-effectiveness analyses, but the decision should also take into account other criteria, such as gender-related equality. Linertová R, Guirado-Fuentes C, Mar Medina J, Imaz-Iglesia I, Rodríguez-Rodríguez L, Carmona-Rodríguez M. Cost-effectiveness of extending the HPV vaccination to boys: a systematic review. J Epidemiol Community Health. 2021 Sep;75(9):910-916. doi: 10.1136/jech-2020-216305. Epub 2021 Jun 23. PMID: 34162740. 10.1136/jech-2020-216305 Journal of Epidemiology & Community Health 34162740 https://hdl.handle.net/20.500.12105/27017 Cost effective Prevention Sexually transmitted diseases Systematic review Vaccination Cost-effectiveness of extending the HPV vaccination to boys: a systematic review.