2026-06-14T03:53:16Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/270032025-12-18T12:57:30Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Hernández-García, Elena author Galán, Miguel author Khouili, Sofía C author Moya-Ruiz, Elena author Redondo-Urzainqui, Ana author Cueto, Francisco J author Martínez-Cano, Saraí author Rodrigo-Tapias, Manuel author Tomasello, Elena author Mañes, Santos author Dalod, Marc author Sancho, David author Iborra, Salvador author 2026-02-02 Resident memory CD8+ T cells (Trms) are essential for protecting barrier nonlymphoid tissues (NLTs) against reinfection, yet the involvement of dendritic cells (DCs) in this process and the nature of Trm-DC interactions within these tissues remain poorly understood. Our study demonstrates that upon reactivation, memory CD8+ T cells located in the skin-independently of circulating memory counterparts-initiate the infiltration and maturation of plasmacytoid DCs (pDCs) in the tissue. This, in turn, promotes the maturation of conventional type 1 DCs (cDC1s) through type I IFN (IFN-I) signaling in a pDC-dependent manner. Depletion of pDCs or blocking IFN-I signaling disrupts this axis, severely impairing Trm-driven protection against secondary infections with vaccinia virus (VACV) in the skin. Notably, this pDC-dependent, IFN-I-mediated pathway is also essential for Trm-mediated protection against secondary respiratory infections with influenza A virus (IAV). Our findings uncover a crucial collaboration between Trm, pDCs, and cDC1s, offering new insights for enhancing vaccines. J Exp Med. 2026 Feb 2;223(2):e20250099. JOURNAL OF EXPERIMENTAL MEDICINE 41288524 https://hdl.handle.net/20.500.12105/27003 pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection.