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oai:repisalud.isciii.es:20.500.12105/269992025-12-11T01:15:36Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587

00925njm 22002777a 4500 dc Wculek, Stefanie K author Forisch, Stephan author Miguel, Verónica author Sancho, David author 2024-09 Macrophages are present in almost all organs. Apart from being immune sentinels, tissue-resident macrophages (TRMs) have organ-specific functions that require a specialized cellular metabolism to maintain homeostasis. In addition, organ-dependent metabolic adaptations of TRMs appear to be fundamentally distinct in homeostasis and in response to a challenge, such as infection or injury. Moreover, TRM function becomes aberrant with advancing age, contributing to inflammaging and organ deterioration, and a metabolic imbalance may underlie TRM immunosenescence. Here, we outline current understanding of the particular metabolic states of TRMs across organs and the relevance for their function. Moreover, we discuss the concomitant aging-related decline in metabolic plasticity and functions of TRMs, highlighting potential novel therapeutic avenues to promote healthy aging. Trends Endocrinol Metab. 2024 Sep;35(9):793-808. TRENDS IN ENDOCRINOLOGY AND METABOLISM 38763781 https://hdl.handle.net/20.500.12105/26999 aging macrophage metabolism organ homeostasis tissue residency Metabolic homeostasis of tissue macrophages across the lifespan.