2026-07-22T03:36:52Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/268502025-12-18T12:58:58Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Guisantes-Batán, Eduardo
author
Artigas-Jerónimo, Sara
author
Mazuecos, Lorena
author
Rubio, Blanca
author
Bonzón-Kulichenko, Elena
author
Gómez, Sergio
author
Villar, Margarita
author
Gallardo, Nilda
funder
University of Castilla-La Mancha (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Unión Europea. Fondo Social Europeo (ESF/FSE)
funder
Unión Europea. Comisión Europea. NextGenerationEU
2025-08-06T12:18:14Z
2025-08-06T12:18:14Z
2025-06-16
Food Funct. 2025 Jun 16;16(12):4784-4794.
Food and Function
40308152
https://hdl.handle.net/20.500.12105/26850
Grape seed extract (GSE) is rich in polyphenols and has garnered attention for its potential health benefits, particularly in the gastrointestinal system. This study explores the principal effects of consuming a low dose of GSE on the intestinal proteome. Using a rat model, we examined the ileum proteomes of rats supplemented with GSE compared with a control group without supplementation. Particularly, this study was conducted using the label-free sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) quantitative proteomics to describe ileum proteome changes derived from GSE flavanols consumption, characterizing its possible mechanisms of action. Our results highlight the substantial impact of GSE on the ileum proteome, suggesting potential mechanisms through which GSE exerts its effects. The observed protein regulation patterns indicate significant alterations in metabolic and immune regulatory pathways, highlighting the importance of considering individual variability and physiological context when evaluating the potential effects of GSE on gastrointestinal function.
eng
Proteome evaluation of the biological activity of grape seed extract (GSE) on the intestine of rats.
research article
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URL
https://repisalud.isciii.es/bitstreams/fbc74409-e351-4f87-9e6f-e669dbe0359d/download
File
MD5
f8d6a120715d429ec5e7183d9a7f1638
1922516
application/pdf
Proteome evaluation of the biological activity_Food Funct_2025.pdf