2026-06-30T01:54:07Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/268472025-07-31T00:19:31Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Mastrangelo, Annalaura
author
Robles-Vera, Iñaki
author
Mañanes, Diego
author
Galán, Miguel
author
Femenía-Muiña, Marcos
author
Redondo-Urzainqui, Ana
author
Barrero-Rodríguez, Rafael
author
Papaioannou, Eleftheria
author
Amores-Iniesta, Joaquín
author
Devesa, Ana
author
Lobo-González, Manuel
author
Carreras, Alba
author
Beck, Katharina R
author
Ivarsson, Sophie
author
Gummesson, Anders
author
Georgiopoulos, Georgios
author
Rodrigo-Tapias, Manuel
author
Martínez-Cano, Sarai
author
Fernández-López, Ivan
author
Nuñez, Vanessa
author
Ferrarini, Alessia
author
Inohara, Naohiro
author
Stamatelopoulos, Kimon
author
Benguría, Alberto
author
Cibrian, Danay
author
Sánchez-Madrid, Francisco
author
Alonso-Herranz, Vanesa
author
Dopazo, Ana
author
Barbas, Coral
author
Vázquez, Jesús
author
López, Juan Antonio
author
González-Martín, Alicia
author
Nuñez, Gabriel
author
Stellos, Konstantinos
author
Bergström, Göran
author
Bäckhed, Fredrik
author
Fuster, Valentín
author
Ibañez, Borja
author
Sancho, David
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Fundación La Caixa
funder
Comunidad de Madrid (España)
funder
Sociedad Española de Cardiología
funder
Unión Europea. Comisión Europea. Horizonte Europa
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Banco Santander
2025-07-30T14:00:27Z
2025-07-30T14:00:27Z
2025-07-16
Nature. 2025 Jul 16.
Nature
40670786
https://hdl.handle.net/20.500.12105/26847
Atherosclerosis is the main underlying cause of cardiovascular diseases. Its prevention is based on the detection and treatment of traditional cardiovascular risk factors. However, individuals at risk for early vascular disease often remain unidentified. Recent research has identified new molecules in the pathophysiology of atherosclerosis, highlighting the need for alternative disease biomarkers and therapeutic targets to improve early diagnosis and therapy efficacy. Here, we observed that imidazole propionate (ImP), produced by microorganisms, is associated with the extent of atherosclerosis in mice and in two independent human cohorts. Furthermore, ImP administration to atherosclerosis-prone mice fed with chow diet was sufficient to induce atherosclerosis without altering the lipid profile, and was linked to activation of both systemic and local innate and adaptive immunity and inflammation. Specifically, we found that ImP caused atherosclerosis through the imidazoline-1 receptor (I1R, also known as nischarin) in myeloid cells. Blocking this ImP-I1R axis inhibited the development of atherosclerosis induced by ImP or high-cholesterol diet in mice. Identification of the strong association of ImP with active atherosclerosis and the contribution of the ImP-I1R axis to disease progression opens new avenues for improving the early diagnosis and personalized therapy of atherosclerosis.
eng
Imidazole propionate is a driver and therapeutic target in atherosclerosis.
research article
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