2026-06-14T03:32:14Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/268442025-12-18T12:57:27Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Casquero-Veiga, Marta
author
Ceron, Carlos
author
Cortes-Canteli, Marta
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación ProCNIC
2025-07-23T13:49:47Z
2025-07-23T13:49:47Z
2025-05-09
Curr Opin Cell Biol. 2025 May 9:95:102528.
Current Opinion in Cell Biology
40347710
https://hdl.handle.net/20.500.12105/26844
Alzheimer's disease (AD) is characterized by a multifactorial pathophysiology. Beyond its classical hallmarks, growing evidence highlights vascular contributions, including hemostatic dysregulation and a prothrombotic state in AD. This review focuses on recent findings concerning two key blood clot components-fibrin(ogen) and platelets-and their roles in AD pathology, including fibrinogen's abnormal accumulation in the AD brain, its interaction with amyloid-β, together with the associated impacts on clot stability, vascular occlusion, and neuroinflammation; and the potential switch of platelets along the AD continuum from protective to deleterious. This review provides an update on the interplay between vascular dysfunction and AD, underscoring the need for comprehensive integrative research to address AD's complexity and advocating for personalized approaches to tackle this multifaceted disorder.
eng
Alzheimer's disease and vascular biology - A focus on the procoagulant state.
research article
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URL
https://repisalud.isciii.es/bitstreams/8a8b56a8-ea53-441a-80d0-1dc379ea719b/download
File
MD5
2ab27cfbd064a1de4899eacf4677a190
2682802
application/pdf
Alzheimer's disease and vascular biology_Curr Opin Cell Biol_2025.pdf