2026-08-29T09:16:53Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/268412025-12-18T13:01:55Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Martinez-Val, Ana author Van der Hoeven, Leander author Bekker-Jensen, Dorte B author Jørgensen, Margarita Melnikova author Nors, Jesper author Franciosa, Giulia author Andersen, Claus L author Bramsen, Jesper B author Olsen, Jesper V author 2025-07 Colorectal cancer molecular signatures derived from omics data can be employed to stratify CRC patients and aid decisions about therapies or evaluate prognostic outcome. However, molecular biomarkers for identification of patients at increased risk of disease relapse are currently lacking. Here, we present a comprehensive multi-omics analysis of a Danish colorectal cancer tumor cohort composed of 412 biopsies from tumors of 371 patients diagnosed at TNM stage II or III. From mass spectrometry-based patient proteome profiles, we classified the tumors into four molecular subtypes, including a mesenchymal-like subtype. As the mesenchymal-rich tumors are known to represent the most invasive and metastatic phenotype, we focused on the protein signature defining this subtype to evaluate their potential as relapse risk markers. Among signature-specific proteins, we followed-up Caveolae-Associated Protein-1 (CAVIN1) and demonstrated its role in tumor progression in a 3D in vitro model of colorectal cancer. Compared to previous omics analyses of CRC, our multi-omics classification provided deeper insights into EMT in cancer cells with stronger correlations with risk of relapse. Mol Syst Biol. 2025 Jul;21(7):776-806. Molecular Systems Biology 40269326 https://hdl.handle.net/20.500.12105/26841 CAVIN1 Colorectal Cancer Proteomics Tumor Relapse Proteomics of colorectal tumors identifies the role of CAVIN1 in tumor relapse.