2026-05-17T00:18:35Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/268342025-12-18T13:01:54Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
de la Cruz, Ester
author
Cadenas, Vanessa
author
Temiño, Susana
author
Oliver, Guillermo
author
Torres, Miguel
funder
Unión Europea. Comisión Europea. H2020
funder
Ministerio de Ciencia e Innovación (España)
funder
Comunidad de Madrid (España)
funder
Ministerio de Educación, Cultura y Deporte (España)
funder
European Molecular Biology Organization
funder
Ministerio de Ciencia e Innovación (España)
funder
Fondation Leducq
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2025-07-16T15:41:32Z
2025-07-16T15:41:32Z
2025-06
EMBO Rep. 2025 Jun;26(11):2803-2818.
EMBO Reports
40128409
https://hdl.handle.net/20.500.12105/26834
The contractile ability of the mammalian heart critically relies on blood coronary circulation, essential to provide oxygen and nutrients to myocardial cells. In addition, the lymphatic vasculature is essential for the myocardial immune response, extracellular fluid homeostasis and response to injury. Recent studies identified different origins of coronary lymphatic endothelial cells, however, the cues that govern coronary lymphangiogenesis remain unknown. Here we show that the coronary lymphatic vasculature develops in intimate contact with the epicardium and with epicardial-derived cells. The epicardium expresses the lymphangiogenic cytokine VEGFC and its conditional deletion in the epicardium abrogates coronary lymphatic vasculature development. Interestingly, VEGFD is also expressed in the epicardium and cooperates with VEGFC in coronary lymphangiogenesis, but it does so only in females, uncovering an unsuspected sex-specific role for this cytokine. These results identify the epicardium/subepicardium as a signaling niche required for coronary lymphangiogenesis and VEGFC/D as essential mediators of this role.
eng
Coronary Vasculature
Heart Development
Lymphatic Vasculature
Sex-specific Gene Function
Vascular Biology
Epicardial VEGFC/D signaling is essential for coronary lymphangiogenesis.
research article
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URL
https://repisalud.isciii.es/bitstreams/4ffde3b8-d491-49de-a747-3c78be491024/download
File
MD5
ee643796a0afee3984a03898dc4f2e5a
14127561
application/pdf
Epicardial VEGFC_D signaling_EMBO Rep_2025.pdf