2026-08-29T10:01:28Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/268332025-12-18T13:01:54Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Ghigo, Alessandra
author
Ameri, Pietro
author
Asnani, Aarti
author
Bertero, Edoardo
author
de Boer, Rudolf A
author
Farmakis, Dimitrios
author
González, Arantxa
author
Heymans, Stephane
author
Ibáñez, Borja
author
López-Fernández, Teresa
author
Lyon, Alexander R
author
Pollesello, Piero
author
Rakisheva, Amina
author
Stellos, Konstantinos
author
Streckfuss-Bömeke, Katrin
author
Tocchetti, Carlo Gabriele
author
Thum, Thomas
author
van der Meer, Peter
author
Van Rooij, Eva
author
Ponikowski, Piotr
author
Metra, Marco
author
Rosano, Giuseppe
author
Van Linthout, Sophie
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Unión Europea. Comisión Europea. H2020
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación La Caixa
funder
Comunidad de Madrid (España)
funder
Fondation Leducq
2025-07-16T14:57:28Z
2025-07-16T14:57:28Z
2025-06
Eur J Heart Fail. 2025 Jun;27(6):1028-1046.
European Journal of Heart Failure
40069106
https://hdl.handle.net/20.500.12105/26833
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the implementation of effective treatments. Therefore, there is a crucial need for appropriate preclinical models to understand the biological basis of their cardiotoxicity. This scientific statement summarizes the preclinical models hitherto used, from in vitro two- and three-dimensional human systems to small and large animals, to pinpoint the molecular mechanisms behind the cardiotoxicity of new-generation anticancer therapies, particularly immunotherapies, and to develop potential cardioprotective strategies. Furthermore, it discusses how preclinical models have contributed to the provocative concept of heart failure being potentially tumorigenic and how the discovery of drugs with both anticancer and cardioprotective actions has revealed a common mechanistic basis for heart failure and cancer. Finally, it discusses the existing gaps between preclinical models and clinical observations in patients, how these discrepancies affect regulatory pathways and the drug development process in cardio-oncology and provides recommendations for closing these gaps.
eng
Anticancer therapy
Cancer
Cardiotoxicity
Immunotherapy
Preclinical models
Update on preclinical models of cancer therapy-related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio-Oncology, and the ESC Working Group on Cellular Biology of the Heart.
research article
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URL
https://repisalud.isciii.es/bitstreams/bb9073c2-f44b-45da-bc82-36df93a1a671/download
File
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1e1ce34363b060f00dc94e236dd66140
1192107
application/pdf
Update on preclinical models of cancer therapy_Eur J Heart Fail_2025.pdf