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oai:repisalud.isciii.es:20.500.12105/268272025-12-18T13:01:56Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587

00925njm 22002777a 4500 dc Dunphy, Gillian author Sancho, David author 2025-04 Increased body temperature, both locally and systemically, is a key feature of the inflammatory response. Heat is associated with increased blood flow to affected areas and increased immune infiltrate, yet increased temperature has also been described to have direct effects on immune cell function. In a recent study, Heintzman, et al investigated the effect of febrile temperature (39 °C) on T cell function. They describe increased T1 function and fitness accompanied by a decrease in regulatory T cell suppressive function. These findings add another important consequence to our understanding of fever responses. Immunometabolism (Cobham). 2025 Mar 13;7(2):e00058. IMMUNOMETABOLISM 40092481 https://hdl.handle.net/20.500.12105/26827 TH1 immunity fever inflammation mitochondria Mitochondrial response to fever boosts T1-driven inflammatory responses.