2026-04-29T04:52:17Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/268102025-12-18T12:57:25Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Robles-Vera, Iñaki
author
Jarit-Cabanillas, Aitor
author
Brandi, Paola
author
Martínez-López, María
author
Martínez-Cano, Sarai
author
Rodrigo-Tapias, Manuel
author
Femenía-Muiña, Marcos
author
Redondo-Urzainqui, Ana
author
Nuñez, Vanesa
author
González-Correa, Cristina
author
Moleón, Javier
author
Duarte, Juan
author
Conejero, Laura
author
Mata-Martínez, Pablo
author
Díez-Rivero, Carmen María
author
Bergón-Gutiérrez, Marta
author
Fernández-López, Iván
author
Gómez, Manuel J
author
Quintas, Ana
author
Dopazo, Ana
author
Sánchez-Cabo, Fátima
author
Pariente, Esther
author
Del Fresno, Carlos
author
Subiza, José Luis
author
Iborra, Salvador
author
Sancho, David
funder
Fundación La Caixa
funder
Comunidad de Madrid (España)
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Asociación Española Contra el Cáncer
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Fundación ProCNIC
2025-07-09T13:06:28Z
2025-07-09T13:06:28Z
2025-02-11
Immunity. 2025 Feb 11;58(2):381-396.e9.
https://hdl.handle.net/20.500.12105/26810
39848243
Immunity
Impairment of the intestinal barrier allows the systemic translocation of commensal bacteria, inducing a proinflammatory state in the host. Here, we investigated innate immune responses following increased gut permeability upon administration of dextran sulfate sodium (DSS) in mice. We found that Enterococcus faecalis translocated to the bone marrow following DSS treatment and induced trained immunity (TI) hallmarks in bone-marrow-derived mouse macrophages and human monocytes. DSS treatment or heat-killed E. faecalis reprogrammed bone marrow progenitors (BMPs), resulting in enhanced inflammatory responses in vitro and in vivo and protection against subsequent pathogen infections. The C-type lectin receptor Mincle (Clec4e) was essential for E. faecalis-induced TI in BMPs. Clec4e mice showed impaired TI upon E. faecalis administration and reduced pathology following DSS treatment. Thus, Mincle sensing of E. faecalis induces TI that may have long-term effects on pathologies associated with increased gut permeability.
eng
Mincle receptor
bone marrow progenitors
gut bacterial translocation
inflammation
macrophages
trained immunity
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow.
research article
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URL
https://repisalud.isciii.es/bitstreams/c958f920-36c3-42da-b19b-fcce98ec3911/download
File
MD5
ab586ee7b68bbe9d2a9c6ae940c38bda
4835535
application/pdf
Microbiota translocation following intestinal_Immunity_2025.pdf