2026-05-17T00:18:32Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/268092025-12-18T13:01:55Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc David, Sánchez-Ortiz author Lucía, Deiros-Bronte author Lucía, De la Hoz-Marañón author Marta, Feito-Rodríguez author Juvenal, Rey-Lois author Diana, Salas-Mera author Carlos, Labrandero-De Lera author Juan Carlos, López-Gutiérrez author Federico, Gutiérrez-Larraya author 2025 PHACE syndrome is an uncommon disorder, marked by large segmental hemangiomas on the face and various developmental anomalies. Significant advancements have been made in its diagnosis, imaging, and understanding of complications since 1996. We describe the first diagnosis case of PHACE syndrome in a one-month and 19-day-old infant who presented with a large facial hemangioma and coarctation of the aorta originating from the left common carotid artery, along with an aberrant course of the right subclavian artery. The complementary diagnostic studies, their surgical correction, and their progression are described. Given the rarity of the syndrome (the PHACE Syndrome International Clinical Registry and Genetic Repository has over 270 enrolled individuals) and the importance of early diagnosis of some anomalies it comprises, particularly cardiovascular anomalies, dissemination is considered crucial for general and pediatric cardiologists. Front Cardiovasc Med. 2025 Feb 3:12:1539168. FRONTIERS IN CARDIOVASCULAR MEDICINE 39963605 https://hdl.handle.net/20.500.12105/26809 PHACE syndrome aortic coarctation aortic malformations hemangioma neural crest migration Case Report: Two-month-old infant with PHACE syndrome: facial hemangioma and severe complex coarctation of the aorta.