2026-05-17T01:26:19Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/267942025-12-18T12:57:23Zcom_20.500.12105_2273com_20.500.12105_2202col_20.500.12105_19571
Repisalud
author
Musteanu, Mónica
author
Blaas, Leander
author
Zenz, Rainer
author
Svinka, Jasmin
author
Hoffmann, Thomas
author
Grabner, Beatrice
author
Schramek, Daniel
author
Kantner, Hans-Peter
author
Müller, Mathias
author
Kolbe, Thomas
author
Rülicke, Thomas
author
Moriggl, Richard
author
Kenner, Lukas
author
Stoiber, Dagmar
author
Penninger, Josef Martin
author
Popper, Helmut
author
Casanova, Emilio
author
Eferl, Robert
funder
European Research Council (ERC)
funder
Institute of Molecular Biotechnology (IMBA)
funder
Austrian Science Fund (FWF)
funder
Ludwig Boltzmann Gesellschaft (LBG)
2025-07-01T12:31:14Z
2025-07-01T12:31:14Z
2012-09
Nat Methods . 2012 Sep;9(9):897-900.
22863881
https://hdl.handle.net/20.500.12105/26794
We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.
eng
oncogenic RAS
CELL
RECOMBINATION
ACTIVATION
A mouse model to identify cooperating signaling pathways in cancer.
research article
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URL
https://repisalud.isciii.es/bitstreams/c314d50c-3f7c-49d9-8520-a228ec9182f0/download
File
MD5
6eba8c2916070045043f8a8d7bef6cda
432518
application/pdf
amousemodel.pdf