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oai:repisalud.isciii.es:20.500.12105/267942025-12-18T12:57:23Zcom_20.500.12105_2273com_20.500.12105_2202col_20.500.12105_19571

00925njm 22002777a 4500 dc Musteanu, Mónica author Blaas, Leander author Zenz, Rainer author Svinka, Jasmin author Hoffmann, Thomas author Grabner, Beatrice author Schramek, Daniel author Kantner, Hans-Peter author Müller, Mathias author Kolbe, Thomas author Rülicke, Thomas author Moriggl, Richard author Kenner, Lukas author Stoiber, Dagmar author Penninger, Josef Martin author Popper, Helmut author Casanova, Emilio author Eferl, Robert author 2012-09 We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis. Nat Methods . 2012 Sep;9(9):897-900. 22863881 https://hdl.handle.net/20.500.12105/26794 oncogenic RAS CELL RECOMBINATION ACTIVATION A mouse model to identify cooperating signaling pathways in cancer.