2026-04-29T01:00:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/267602025-12-18T13:01:20Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Martín, Pilar
author
Sánchez-Madrid, Francisco
funder
Comunidad de Madrid (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Fundación La Marató TV3
funder
Fundación La Caixa
funder
Instituto de Salud Carlos III
funder
Agencia Estatal de Investigación (España)
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2025-06-17T11:25:59Z
2025-06-17T11:25:59Z
2025-01-16
J Clin Invest. 2025 Jan 16;135(2):e185218.
https://hdl.handle.net/20.500.12105/26760
39817455
Journal of Clinical Investigation
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide, with inflammation playing a pivotal role in its pathogenesis. T lymphocytes are crucial components of the adaptive immune system that have emerged as key mediators in both cardiac health and the development and progression of CVD. This Review explores the diverse roles of T cell subsets, including Th1, Th17, γδ T cells, and Tregs, in myocardial inflammatory processes such as autoimmune myocarditis and myocardial infarction. We discuss the contribution of T cells to myocardial injury and remodeling, with emphasis on specific immune receptors, e.g., CD69, that have a critical role in regulating immune tolerance and maintaining the balance between T cell subsets in the heart. Additionally, we offer a perspective on recent advances in T cell-targeted therapies and their potential to modulate immune responses and improve clinical outcomes in patients with CVD and in heart transplant recipients. Understanding the intricate interplay between T cells and cardiovascular pathology is essential for developing novel immunotherapeutic strategies against CVD.
eng
T cells in cardiac health and disease.
review
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URL
https://repisalud.isciii.es/bitstreams/d117e8d6-190f-4914-8bbe-63dc658c98f2/download
File
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2401358
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T cells in cardiac health_J Clin Invest_2025.pdf