2026-05-21T23:06:54Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/267592025-12-18T12:56:52Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Cicuéndez, Beatriz
author
Mora, Alfonso
author
López, Juan Antonio
author
Curtabbi, Andrea
author
Pérez-García, Javier
author
Porteiro, Begoña
author
Jimenez-Blasco, Daniel
author
Latorre-Muro, Pedro
author
Vo, Paula
author
Jerome, Madison
author
Gómez-Santos, Beatriz
author
Romero-Becerra, Rafael
author
Leiva, Magdalena
author
Rodríguez, Elena
author
León, Marta
author
Leiva-Vega, Luis
author
Gómez-Lado, Noemi
author
Torres, Jorge L
author
Hernández-Cosido, Lourdes
author
Aguiar, Pablo
author
Marcos, Miguel
author
Jastroch, Martin
author
Daiber, Andreas
author
Aspichueta, Patricia
author
Bolaños, Juan Pedro
author
Spinelli, Jessica B
author
Puigserver, Pere
author
Enriquez, José Antonio
author
Vázquez, Jesús
author
Folgueira, Cintia
author
Sabio, Guadalupe
funder
Fundación La Caixa
funder
Novo Nordisk Foundation
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Fundación BBVA
funder
Fundación Lilly
funder
Comunidad de Madrid (España)
funder
Asociación Española Contra el Cáncer
funder
National Institutes of Health (Estados Unidos)
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2025-06-17T10:53:14Z
2025-06-17T10:53:14Z
2025-01-13
Nat Commun. 2025 Jan 13;16(1):229.
Nature Communications
39805849
https://hdl.handle.net/20.500.12105/26759
Obesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how MCJ expression decreases during obesity, as evident in human and mouse adipose tissue samples. MCJ mice, even without UCP1, a fundamental thermogenic protein, exhibit elevated BAT thermogenesis. Electron microscopy unveils changes in mitochondrial morphology resembling BAT activation. Proteomic analysis confirms these findings and suggests involvement of the eIF2α mediated stress response. The pivotal role of eIF2α is scrutinized by in vivo CRISPR deletion of eIF2α in MCJ mice, abrogating thermogenesis. These findings uncover the importance of MCJ as a regulator of BAT thermogenesis, presenting it as a promising target for obesity therapy.
eng
Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis.
research article
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URL
https://repisalud.isciii.es/bitstreams/28956ddc-d86b-4510-8c9e-f0a4e2fc84e6/download
File
MD5
13bd925b8e2e9b1088022fc587692c3f
4660299
application/pdf
Absence of MCJ_DnaJC15_Nat Commun_2025.pdf