2026-05-22T00:16:30Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/267592025-12-18T12:56:52Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Cicuéndez, Beatriz author Mora, Alfonso author López, Juan Antonio author Curtabbi, Andrea author Pérez-García, Javier author Porteiro, Begoña author Jimenez-Blasco, Daniel author Latorre-Muro, Pedro author Vo, Paula author Jerome, Madison author Gómez-Santos, Beatriz author Romero-Becerra, Rafael author Leiva, Magdalena author Rodríguez, Elena author León, Marta author Leiva-Vega, Luis author Gómez-Lado, Noemi author Torres, Jorge L author Hernández-Cosido, Lourdes author Aguiar, Pablo author Marcos, Miguel author Jastroch, Martin author Daiber, Andreas author Aspichueta, Patricia author Bolaños, Juan Pedro author Spinelli, Jessica B author Puigserver, Pere author Enriquez, José Antonio author Vázquez, Jesús author Folgueira, Cintia author Sabio, Guadalupe author 2025-01-13 Obesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how MCJ expression decreases during obesity, as evident in human and mouse adipose tissue samples. MCJ mice, even without UCP1, a fundamental thermogenic protein, exhibit elevated BAT thermogenesis. Electron microscopy unveils changes in mitochondrial morphology resembling BAT activation. Proteomic analysis confirms these findings and suggests involvement of the eIF2α mediated stress response. The pivotal role of eIF2α is scrutinized by in vivo CRISPR deletion of eIF2α in MCJ mice, abrogating thermogenesis. These findings uncover the importance of MCJ as a regulator of BAT thermogenesis, presenting it as a promising target for obesity therapy. Nat Commun. 2025 Jan 13;16(1):229. Nature Communications 39805849 https://hdl.handle.net/20.500.12105/26759 Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis.