2026-08-29T16:26:35Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/267542025-12-18T12:56:52Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Cabrera-Alarcon, José Luis
author
Cruz, Raquel
author
Rosa-Moreno, Marina
author
Latorre-Pellicer, Ana
author
de Almeida, Silvia Diz
author
Riancho, José A
author
Rojas-Martinez, Augusto
author
Flores, Carlos
author
Lapunzina, Pablo
author
Sánchez-Cabo, Fátima
author
Carracedo, Ángel
author
Enriquez, José Antonio
funder
Fondation Leducq
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Plan de Recuperación, Transformación y Resiliencia (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Banco Santander
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2025-06-16T15:04:19Z
2025-06-16T15:04:19Z
2025-01-09
Commun Biol. 2025 Jan 9;8(1):33.
Communications Biology
39789223
https://hdl.handle.net/20.500.12105/26754
The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest trained model for mitochondrial haplogroup calling using data procured from GWAS arrays. Our results reveal that in the context of the SARS-CoV-2 pandemic, HV branch were found to represent protective factors against the development of critical SARS-CoV-2 in an analysis of 14,349 patients. These results highlight the role of mtDNA in the response to infectious diseases and support the proposal that its expansion and population proportion has been influenced by selection through successive pandemics.
eng
Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity.
journal article
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URL
https://repisalud.isciii.es/bitstreams/6592e5b4-367d-43dc-ad5e-d00cddcc31fe/download
File
MD5
f30429499fd09fc94e945a1f7ce8efb5
1165466
application/pdf
Shaping current European mitochondrial_Commun Biol_2025.pdf