2026-05-21T23:07:05Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/267542025-12-18T12:56:52Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587

00925njm 22002777a 4500 dc Cabrera-Alarcon, José Luis author Cruz, Raquel author Rosa-Moreno, Marina author Latorre-Pellicer, Ana author de Almeida, Silvia Diz author Riancho, José A author Rojas-Martinez, Augusto author Flores, Carlos author Lapunzina, Pablo author Sánchez-Cabo, Fátima author Carracedo, Ángel author Enriquez, José Antonio author 2025-01-09 The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest trained model for mitochondrial haplogroup calling using data procured from GWAS arrays. Our results reveal that in the context of the SARS-CoV-2 pandemic, HV branch were found to represent protective factors against the development of critical SARS-CoV-2 in an analysis of 14,349 patients. These results highlight the role of mtDNA in the response to infectious diseases and support the proposal that its expansion and population proportion has been influenced by selection through successive pandemics. Commun Biol. 2025 Jan 9;8(1):33. Communications Biology 39789223 https://hdl.handle.net/20.500.12105/26754 Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity.