2026-04-29T16:56:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/267532025-12-18T13:01:20Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Rueda-Alaña, Eneritz
author
Senovilla-Ganzo, Rodrigo
author
Grillo, Marco
author
Vázquez, Enrique
author
Marco-Salas, Sergio
author
Gallego-Flores, Tatiana
author
Ordeñana-Manso, Aitor
author
Ftara, Artemis
author
Escobar, Laura
author
Benguría, Alberto
author
Quintas, Ana
author
Dopazo, Ana
author
Rábano, Miriam
author
Vivanco, María dM
author
Aransay, Ana María
author
Garrigos, Daniel
author
Toval, Ángel
author
Ferrán, José Luis
author
Nilsson, Mats
author
Encinas-Pérez, Juan Manuel
author
De Pittà, Maurizio
author
García-Moreno, Fernando
funder
Ikerbasque - Basque Foundation for Science
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia
2025-06-16T14:33:42Z
2025-06-16T14:33:42Z
2025-01-02
Science . 2025 Jan 2;387(6735):eadp3411.
Science
39946453
https://hdl.handle.net/20.500.12105/26753
The amniote pallium contains sensory circuits that are structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. We used birthdating analysis, single-cell RNA and spatial transcriptomics, and mathematical modeling to compare the development and evolution of known pallial circuits across birds (chick), lizards (gecko), and mammals (mouse). We reveal that neurons within these circuits' stations are generated at varying developmental times and brain regions across species and found an early developmental divergence in the transcriptomic progression of glutamatergic neurons. Our research highlights developmental distinctions and functional similarities in the sensory circuit between birds and mammals, suggesting the convergence of high-order sensory processing across amniote lineages.
eng
Evolutionary convergence of sensory circuits in the pallium of amniotes.
research article
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URL
https://repisalud.isciii.es/bitstreams/074b0e5b-51b8-41a3-a74c-d93b98eab849/download
File
MD5
aca6f10c36f005f8db4c2f175d03b48c
6000975
application/pdf
Evolutionary convergence of sensory circuits_Science_2025.pdf