2026-06-14T03:33:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/267292025-12-18T13:01:17Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19612col_20.500.12105_16939col_20.500.12105_16980
Repisalud
author
Sanchez-Piedra, Carlos
author
Rodriguez Ortiz de Salazar, Begoña
author
Roca, Oriol
author
Prado-Galbarro, Francisco-Javier
author
Perestelo-Perez, Lilisbeth
author
Sanchez-Gomez, Luis Maria
2025-06-10T12:09:08Z
2025-06-10T12:09:08Z
2025-02-26
Sanchez-Piedra C, Rodríguez-Ortiz-de-Salazar B, Roca O, Prado-Galbarro FJ, Perestelo-Perez L, Sanchez-Gomez LM. Electrical impedance tomography for PEEP titration in ARDS patients: a systematic review and meta-analysis. J Clin Monit Comput. 2025 Feb 26.
10.1007/s10877-025-01266-2
1573-2614
1387-1307
Journal of clinical monitoring and computing
40011398
https://hdl.handle.net/20.500.12105/26729
To assess the efficacy of electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration in improving outcomes for patients with acute respiratory distress syndrome (ARDS). A systematic review and meta-analysis was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Randomized controlled trials and observational studies with a control group comparing EIT-guided PEEP titration to other strategies were included. Endpoints analysed included mortality, days of mechanical ventilation (MV), intensive care unit (ICU) length of stay (LOS), weaning success rate, barotrauma, driving pressure (∆P), mechanical power (MP), Sequential Organ Failure Assessment (SOFA) score and adverse events. Pooled results were presented as Risk Ratio (RR) for dichotomous outcomes and standardized difference in means (SMD) for continuous outcomes. A total of 4 studies were identified (3 randomized controlled trials and one observational study). All studies were single-center studies (N total = 271 patients). The main limitations were related to potential bias in selecting reported outcomes. EIT-guided PEEP titration was associated with a significant reduction in mortality among critically ill patients with ARDS (RR = 0.64, 95% CI: 0.45-0.91). No significant differences were found in other outcomes. Our findings suggest that EIT may be a valuable tool for PEEP titration in critically ill patients with ARDS. By optimizing lung mechanics, EIT-guided PEEP titration may potentially reduce mortality rates. While larger, multicenter studies are needed to definitively establish the clinical role of EIT in ARDS management, our results provide promising evidence for its potential clinical impact.
eng
Acute respiratory distress syndrome
Positive end-expiratory pressure
Critical care
Electrical impedance tomography
Mechanical ventilation
Electrical impedance tomography for PEEP titration in ARDS patients: a systematic review and meta-analysis
review article
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ElectricalImpedanceTomographyPEEP_2025.pdf
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Supplementary_ElectricalImpedanceTomographyPEEP_2025.pdf