2026-05-17T01:18:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/266542025-12-18T12:59:34Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16988
Repisalud
author
Monge-Maillo, Begoña
author
Roger-Zapata, Daniel
author
Dronda, Fernando
author
Carrillo, Eugenia
author
Moreno, Javier
author
Corbacho-Loarte, María Dolores
author
Gayoso Cantero, Diego
author
Martín, Oihane
author
Chamorro-Tojeiro, Sandra
author
Perez-Molina, Jose A
author
Norman, Francesca
author
González-Sanz, Marta
author
López-Vélez, Rogelio
2025-05-13T09:15:26Z
2025-05-13T09:15:26Z
2025-03-19
Monge-Maillo B, Roger-Zapata D, Dronda F, Carrillo E, Moreno J, Corbacho-Loarte MD, Gayoso Cantero D, Martín O, Chamorro-Tojeiro S, Perez-Molina JA, Norman F, González-Sanz M, López-Vélez R. Case Report: Long-Term Follow-Up of Visceral Leishmaniasis and HIV Coinfected Patients Without Relapse: Lymphoproliferative Response After Stimulation with Soluble Leishmania Antigen. Microorganisms. 2025 Mar 19;13(3):686.
10.3390/microorganisms13030686
2076-2607
Microorganisms
40142579
https://hdl.handle.net/20.500.12105/26654
Highly active antiretroviral therapy (HAART) has reduced the incidence of VL/HIV dramatically. However, HAART only partially prevents relapses, with one-year relapse rates ranging from 30 to 60%. Consequently, secondary prophylaxis is recommended for patients with <200 CD4+ cells/μL. In clinical practice, characterizing cellular immune response could help estimate the risk of relapse in VL/HIV coinfected patients. In this study, the lymphoproliferative response after stimulation with soluble antigen was assessed in 2022 and 2023 in three cases of VL/HIV coinfection with long-term follow-up (17, 8 and 19 years). PCR and rK-39 results for , HIV viral load, CD4 cell count, proliferation index, IFN-γ, IL-2, IP-10, IL-10 and TNF-α were determined. Heterogeneous results were obtained, with only one patient having developed specific cellular immunity against . No cases of relapse were observed. The heterogeneity of lymphoproliferative test results in the three cases described highlights the need to identify surrogate markers of cure to guide maintenance or withdrawal of prophylaxis.
eng
HIV
Lymphoproliferative response
Recurrence
Relapse
Secondary prevention
Visceral leishmaniasis
Case Report: Long-Term Follow-Up of Visceral Leishmaniasis and HIV Coinfected Patients Without Relapse: Lymphoproliferative Response After Stimulation with Soluble Antigen
research article
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URL
https://repisalud.isciii.es/bitstreams/11c4af63-fc3a-4a3f-bf18-0a714d3b8674/download
File
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6cdca41be50406c474f8a7a81bc10ae6
1361853
application/pdf
CaseReportLong-TermFollow-UpVisceralLeishmaniasis_2025.pdf