2026-05-19T00:55:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/266002025-12-18T13:01:21Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16938col_20.500.12105_16963col_20.500.12105_16977
Repisalud
author
Martín-Antonio, Beatriz
author
Blanco, Belén
author
González-Murillo, África
author
Hidalgo, Laura
author
Minguillón, Jordi
author
Pérez-Chacón, Gema
author
Next Generation CART MAD Consortium
author
Rodriguez-Milla, Miguel A
author
García-Rodriguez, Patricia
author
Somovilla-Crespo, Beatriz
author
Garcia-Castro, Javier
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
2025-03-31T12:12:20Z
2025-03-31T12:12:20Z
2024
Martín-Antonio B, Blanco B, González-Murillo Á, Hidalgo L, Minguillón J, Pérez-Chacón G; Next Generation CART MAD Consortium. Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations. Front Immunol. 2024 May 8;15:1386856.
10.3389/fimmu.2024.1386856
1664-3224
Frontiers in immunology
38779672
https://hdl.handle.net/20.500.12105/26600
Adoptive T cellular immunotherapies have emerged as relevant approaches for treating cancer patients who have relapsed or become refractory (R/R) to traditional cancer treatments. Chimeric antigen receptor (CAR) T-cell therapy has improved survival in various hematological malignancies. However, significant limitations still impede the widespread adoption of these therapies in most cancers. To advance in this field, six research groups have created the "NEXT Generation CART MAD Consortium" (NEXT CART) in Madrid's Community, which aims to develop novel cell-based immunotherapies for R/R and poor prognosis cancers. At NEXT CART, various basic and translational research groups and hospitals in Madrid concur to share and synergize their basic expertise in immunotherapy, gene therapy, and immunological synapse, and clinical expertise in pediatric and adult oncology. NEXT CART goal is to develop new cell engineering approaches and treatments for R/R adult and pediatric neoplasms to evaluate in multicenter clinical trials. Here, we discuss the current limitations of T cell-based therapies and introduce our perspective on future developments. Advancement opportunities include developing allogeneic products, optimizing CAR signaling domains, combining cellular immunotherapies, multi-targeting strategies, and improving tumor-infiltrating lymphocytes (TILs)/T cell receptor (TCR) therapy. Furthermore, basic studies aim to identify novel tumor targets, tumor molecules in the tumor microenvironment that impact CAR efficacy, and strategies to enhance the efficiency of the immunological synapse between immune and tumor cells. Our perspective of current cellular immunotherapy underscores the potential of these treatments while acknowledging the existing hurdles that demand innovative solutions to develop their potential for cancer treatment fully.
eng
CAR-T cells
NK cells
TCR therapy
TILs
Cancer
Immunological synapse
Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations
research article
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NewerGenerationsMulti-target_CAR_STAb-T_2024.pdf