2026-05-11T15:08:15Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/265982025-12-18T13:01:38Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Gómez-Bravo, Andrea
author
Cirignoli, Sebastián
author
Wehrendt, Diana
author
Schijman, Alejandro
author
León, Cielo M
author
Flores-Chavez, Maria
author
Nieto Martinez, Francisco Javier
author
Kieran, Troy J
author
Abril, Marcelo
author
Guhl, Felipe
funder
Fundación Mundo Sano
funder
Inter-American Development Bank
2025-03-31T11:26:12Z
2025-03-31T11:26:12Z
2024-06-25
Gómez-Bravo A, Cirignoli S, Wehrendt D, Schijman A, León CM, Flores-Chaves M, Nieto J, Kieran TJ, Abril M, Guhl F. Zoonotic Cycle of American Trypanosomiasis in an Endemic Region of the Argentine Chaco, Factors That Influenced a Paradigm Shift. Insects. 2024 Jun 25;15(7):471.
10.3390/insects15070471
2075-4450
Insects
39057204
https://hdl.handle.net/20.500.12105/26598
Trypanosoma cruzi, the causative agent of Chagas disease (American trypanosomiasis), is a highly complex zoonosis that is present throughout South America, Central America, and Mexico. The transmission of this disease is influenced by various factors, including human activities like deforestation and land use changes, which may have altered the natural transmission cycles and their connection to the environment. In this study conducted in the Argentine Chaco region, we examined the transmission dynamics of T. cruzi by collecting blood samples from wild and domestic animals, as well as triatomine bugs from human dwellings, across five sites of varying anthropic intervention. Samples were analyzed for T. cruzi infection via qPCR, and we additionally examined triatomines for bloodmeal analysis via NGS amplicon sequencing. Our analysis revealed a 15.3% infection rate among 20 wild species (n = 123) and no T. cruzi presence in 9 species of domestic animals (n = 1359) or collected triatomines via qPCR. Additionally, we found chicken (34.28%), human (21.59%), and goat (19.36%) as the predominant bloodmeal sources across all sites. These findings suggest that anthropic intervention and other variables analyzed may have directly impacted the spillover dynamics of T. cruzi's sylvatic cycle and potentially reduced its prevalence in human habitats.
eng
Chagas disease
Trypanosoma cruzi
Human intervention
Spillover
Triatomines
Vector control
Zoonosis
Zoonotic Cycle of American Trypanosomiasis in an Endemic Region of the Argentine Chaco, Factors That Influenced a Paradigm Shift
research article
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URL
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ZoonoticCycleAmericanTrypanosomiasis_2024.pdf
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