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oai:repisalud.isciii.es:20.500.12105/265962025-12-18T12:59:59Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16963col_20.500.12105_16964col_20.500.12105_16982

00925njm 22002777a 4500 dc Garcia-Sanchez, Paula author Romero-Trancón, David author Falces-Romero, Iker author Navarro Carrera, Paula author Ruiz-Carrascoso, Guillermo author Carmena, David author Casares Jiménez, María author Rivero-Juarez, Antonio author Moya, Laura author Rodón, Jaume author Esperón, Fernando author Pérez-Hernando, Belén author Sánchez-León, Rocío author Hurtado-Gallego, Jara author Alcolea, Sonia author Sainz, Talia author Calvo, Cristina author Méndez-Echevarría, Ana author 2024 Introduction: Although pets provide several social-emotional benefits for children, the risk of zoonosis must be considered among immunocompromised individuals. Methods: A prospective study was conducted in a tertiary hospital including immunocompromised patients younger than 20 years owning dogs and/or cats. Colonization and/or infection was evaluated by stool studies, bacterial swabs, blood polymerase chain reaction and serological studies in both patients and their pets, to evaluate potential zoonotic transmission occurrence. Results: We included 74 patients and their 92 pets (63 dogs, 29 cats). Up to 44.6% of the patients and 31.5% of the pets had at least 1 positive result. Up to 18.4% of pets' fecal samples were positive (bacteria, parasites or hepatitis E virus). No helminths were observed despite the high frequency of incorrect intestinal deworming practices. Among children, gastrointestinal microorganisms were found in 37.3% (primarily Clostridium difficile). Colonization by Staphylococcus pseudintermedius was common among pets (8.0%) but not among children (0.0%). No shared colonization between owners and pets was observed, except in one case (Blastocystis in both patient and pet feces). Among patients, serologies were positive for Strongyloides stercoralis (14.8%), Toxocara canis (3.2%), Bartonella henselae (19.1%) and hepatitis E (5.6%). Serology was positive for Rickettsia spp. (22.6%) and Babesia spp. (6.5%) in dogs and for Leishmania spp. (14.3%) and Toxoplasma spp. (14.3%) in cats. Conclusion: Exposure to zoonotic agents was detected in both patients and pets; however, shared colonization events were almost nonexistent. In our cohort, dogs and cats do not appear to entail high zoonosis transmission risk for immunocompromised patients. Garcia-Sanchez P, Romero-Trancón D, Falces-Romero I, Navarro Carrera P, Ruiz-Carrascoso G, Carmena D, Casares Jiménez M, Rivero-Juárez A, Moya L, Rodón J, Esperón F, Pérez-Hernando B, Sánchez-León R, Hurtado-Gallego J, Alcolea S, Sainz T, Calvo C, Méndez-Echevarría A. Zoonosis screening in Spanish immunocompromised children and their pets. Front Vet Sci. 2024 Jul 23;11:1425870. 10.3389/fvets.2024.1425870 2297-1769 Frontiers in veterinary science 39109349 https://hdl.handle.net/20.500.12105/26596 Children Colonization Emerging pathogens Immunocompromised Infection Pets Zoonoses Zoonosis screening in Spanish immunocompromised children and their pets