2026-05-20T04:01:57Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/265622025-12-18T13:01:33Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16988

00925njm 22002777a 4500 dc Corbacho-Loarte, María Dolores author Martín, Oihane author Chamorro-Tojeiro, Sandra author Crespillo-Andújar, Clara author Norman, Francesca F author Pérez-Molina, José A author Sanz, Marta González author Cancio-Suárez, Marta Rosas author Ruiz-Calvo, Gabriel author López, Alberto Richart author Rubio Muñoz, Jose Miguel author López-Vélez, Rogelio author Monge-Maillo, Begoña author 2024-06-06 Background: In non-endemic countries, malaria can be transmitted through blood donations from imported cases. To ensure standards of quality and safety of human blood, the European Union and Spanish national law, requires a deferral period, or a screening by immunological or genomic test among those donors with potential risk of malaria. Scientific societies, European Committee on Blood Transfusion, and Spanish Society of Haematology and Haemotherapy, refer only to the result of the immunological test. Methods: An observational retrospective study was performed in potential donors with a positive immunological test for malaria done in the Regional Transfusion Center in Madrid and referred to the National Reference Unit for Tropical Diseases in Madrid between 2015-2020. At consultation a Polymerase Chain Reaction (PCR) for malaria was performed. Results: During the study period, 121 possible donors attended for consultation at NRU-Trop. Median age: 38.5 (IQR:33-48); median time to consultation was 32 months (IQR:12.5-110). Eighty-two (67.8%) donors were migrants and thirty-nine were travellers (32.2%). ELISA values were available for 109 subjects (90.1%), 56 individual left malaria endemic area > 3 years before. All donors tested negative for Plasmodium spp PCR test (n = 121, 100%). Conclusions: None of the subjects with a positive immunologic test deferred as blood donors had a positive genomic test. The presence of Plasmodium spp in collected blood was not detected by molecular techniques. To avoid the loss of potential blood donors, especially those with low incidence red blood cell antigens, as more precise microbiology techniques become available, updating the existing legislation becomes necessary to increase the availability of donated blood. Corbacho-Loarte MD, Martín O, Chamorro-Tojeiro S, Crespillo-Andújar C, Norman FF, Pérez-Molina JA, Sanz MG, Cancio-Suárez MR, Ruiz-Calvo G, López AR, Rubio JM, López-Vélez R, Monge-Maillo B. Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study. Malar J. 2024 Jun 6;23(1):179. 10.1186/s12936-024-04966-3 1475-2875 Malaria journal 38844954 https://hdl.handle.net/20.500.12105/26562 Plasmodium Asymptomatic infection Immigrants Malaria Transfusion Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study