2026-04-29T00:59:48Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/265382025-12-18T13:01:34Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587

00925njm 22002777a 4500 dc Nuche, Jorge author Ponz, Inés author Sánchez Sánchez, Violeta author Bóbeda, Javier author Gaitán, Ángel author López-Linares, Karen author García-Cosío, María Dolores author Sarnago Cebada, Fernando author González, Javier Sánchez author Arribas Ynsaurriaga, Fernando author Ruíz-Cabello, Jesús author Ibáñez, Borja author Delgado, Juan F author 2025-01-31 Noninvasive techniques for diagnosing combined postcapillary pulmonary hypertension (CpcPH) are unavailable. : To assess the diagnostic performance of cardiac magnetic resonance (CMR)-based four-dimensional (4D)-flow analysis in identifying CpcPH. : Prospective observational study of heart failure (HF) patients with suspected pulmonary hypertension (PH) who underwent simultaneous CMR and right heart catheterization. The 4D-flow biomarkers were calculated using an automatic pipeline. A predictive model including 4D-flow biomarkers associated with CpcPH with a -value < 0.20 was built to determine the diagnostic performance of 4D-flow analysis to identify CpcPH. : A total of 46 HF patients (55.4 ± 14 years, 63% male) with confirmed PH (19 [41%] isolated postcapillary PH [IpcPH], 27 [59%] CpcPH) were included. No differences were found in baseline characteristics, echocardiography, or CMR anatomical and functional parameters, except for a higher Doppler-estimated systolic pulmonary pressure and larger pulmonary artery in CpcPH patients. The 4D-flow CMR analysis was performed in 31 patients (67%). The maximal peak velocity (67.1 [62.2-77.5] cm/s-IpcPH vs. 58.2 [45.8-66.0] cm/s-CpcPH; = 0.021) and maximal helicity (339.9 [290.0-391.8]) cm/s-IpcPH vs. 226.0 (173.5-343.7) cm/s-CpcPH; = 0.026) were significantly lower in patients with CpcPH. A maximal multivariable model including sex, maximal average, and peak velocities, Reynolds number, flow rate, and helicity showed fair diagnostic performance (area under the curve: 0.768 [95%-CI: 0.572-0.963]; sensitivity: 100%; specificity: 55%). : In HF patients with PH, 4D-flow-derived maximal peak velocity and maximal helicity were significantly lower in CpcPH patients. A multiparametric model including maximal 4D-flow-derived biomarkers showed good diagnostic performance for identifying CpcPH. J Clin Med. 2025 Jan 31;14(3):929. https://hdl.handle.net/20.500.12105/26538 39941600 Journal of Clinical Medicine four-dimensional flow heart failure magnetic resonance pulmonary hypertension Four-Dimensional Magnetic Resonance Pulmonary Flow Imaging for Assessing Pulmonary Vasculopathy in Patients with Postcapillary Pulmonary Hypertension.