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oai:repisalud.isciii.es:20.500.12105/264892025-12-18T13:01:28Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Iglesias-Caballero, Maria author Mas-Lloret, Vicente author Vázquez-Morón, Sonia author Vazquez-Alcaraz, Monica author Camarero-Serrano, Sara author Cano, Olga author Palomo-Sanz, Concepcion author Ruano, María José author Cano-Gómez, Cristina author Infantes-Lorenzo, Jose Antonio author Campoy, Albert author Agüero, Montserrat author Pozo Sanchez, Francisco author Casas Flecha, Inmaculada author 2024-05-17 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects various mammalian species, with farmed minks experiencing the highest number of outbreaks. In Spain, we analyzed 67 whole genome sequences and eight spike sequences from 18 outbreaks, identifying four distinct lineages: B.1, B.1.177, B.1.1.7, and AY.98.1. The potential risk of transmission to humans raises crucial questions about mutation accumulation and its impact on viral fitness. Sequencing revealed numerous not-lineage-defining mutations, suggesting a cumulative mutation process during the outbreaks. We observed that the outbreaks were predominantly associated with different groups of mutations rather than specific lineages. This clustering pattern by the outbreaks could be attributed to the rapid accumulation of mutations, particularly in the ORF1a polyprotein and in the spike protein. Notably, the mutations G37E in NSP9, a potential host marker, and S486L in NSP13 were detected. Spike protein mutations may enhance SARS-CoV-2 adaptability by influencing trimer stability and binding to mink receptors. These findings provide valuable insights into mink coronavirus genetics, highlighting both host markers and viral transmission dynamics within communities. Iglesias-Caballero M, Mas V, Vázquez-Morón S, Vázquez M, Camarero-Serrano S, Cano O, Palomo C, Ruano MJ, Cano-Gómez C, Infantes-Lorenzo JA, Campoy A, Agüero M, Pozo F, Casas I. Genomic Context of SARS-CoV-2 Outbreaks in Farmed Mink in Spain during Pandemic: Unveiling Host Adaptation Mechanisms. Int J Mol Sci. 2024 May 17;25(10):5499. 1422-0067 https://hdl.handle.net/20.500.12105/26489 38791536 10.3390/ijms25105499 International journal of molecular sciences NGS SARS-CoV-2 Minks Genomic Context of SARS-CoV-2 Outbreaks in Farmed Mink in Spain during Pandemic: Unveiling Host Adaptation Mechanisms