2026-05-22T00:28:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/264382025-12-18T12:59:18Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Clark, Julia E
author
Kim, Hannah Yejin
author
van de Sande, Wendy W J
author
McMullan, Brendan
author
Verweij, Paul
author
Alastruey-Izquierdo, Ana
author
Chakrabarti, Arunaloke
author
Harrison, Thomas S
author
Bongomin, Felix
author
Hay, Roderick J
author
Oladele, Rita
author
Heim, Jutta
author
Beyer, Peter
author
Galas, Marcelo
author
Siswanto, Siswanto
author
Dagne, Daniel Argaw
author
Roitberg, Felipe
author
Gigante, Valeria
author
Beardsley, Justin
author
Sati, Hatim
author
Alffenaar, Jan-Willem
author
Morrissey, C Orla
funder
Federal Ministry of Education, Science and Research (Austria)
funder
Federal Ministry of Education & Research (Alemania)
2025-03-12T14:10:44Z
2025-03-12T14:10:44Z
2024-06-27
Clark JE, Kim HY, van de Sande WWJ, McMullan B, Verweij P, Alastruey-Izquierdo A, Chakrabarti A, Harrison TS, Bongomin F, Hay RJ, Oladele R, Heim J, Beyer P, Galas M, Siswanto S, Dagne DA, Roitberg F, Gigante V, Beardsley J, Sati H, Alffenaar JW, Morrissey CO. Eumycetoma causative agents: A systematic review to inform the World Health Organization priority list of fungal pathogens. Med Mycol. 2024 Jun 27;62(6):myae044.
10.1093/mmy/myae044
1460-2709
1369-3786
Medical mycology
38935904
https://hdl.handle.net/20.500.12105/26438
The World Health Organization, in response to the growing burden of fungal disease, established a process to develop a fungal priority pathogens list. This systematic review aimed to evaluate the epidemiology and impact of eumycetoma. PubMed and Web of Science were searched to identify studies published between 1 January 2011 and 19 February 2021. Studies reporting on mortality, inpatient care, complications and sequelae, antifungal susceptibility, risk factors, preventability, annual incidence, global distribution, and emergence during the study time frames were selected. Overall, 14 studies were eligible for inclusion. Morbidity was frequent with moderate to severe impairment of quality of life in 60.3%, amputation in up to 38.5%, and recurrent or long-term disease in 31.8%-73.5% of patients. Potential risk factors included male gender (56.6%-79.6%), younger age (11-30 years; 64%), and farming occupation (62.1%-69.7%). Mycetoma was predominantly reported in Sudan, particularly in central Sudan (37%-76.6% of cases). An annual incidence of 0.1/100 000 persons and 0.32/100 000 persons/decade was reported in the Philippines and Uganda, respectively. In Uganda, a decline in incidence from 3.37 to 0.32/100 000 persons between two consecutive 10-year periods (2000-2009 and 2010-2019) was detected. A community-based, multi-pronged prevention programme was associated with a reduction in amputation rates from 62.8% to 11.9%. With the pre-specified criteria, no studies of antifungal drug susceptibility, mortality, and hospital lengths of stay were identified. Future research should include larger cohort studies, greater drug susceptibility testing, and global surveillance to develop evidence-based treatment guidelines and to determine more accurately the incidence and trends over time.
eng
Falciformispora senegalensis
Madurella mycetomatis
Trematosphaeria grisea
Complications
Eumycetoma
Incidence
Mycetoma
Mycosis
Risk factors
Skin
Subcutaneous tissue
Eumycetoma causative agents: A systematic review to inform the World Health Organization priority list of fungal pathogens
research article
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EumycetomaCausativeAgentsSystematicReview_2024.pdf
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Supplementary_EumycetomaCausativeAgentsSystematicReview_2024.pdf