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Repisalud author Pires Simoes, Margarida author Hodcroft, Emma B author Simmonds, Peter author Albert, Jan author Alidjinou, Enagnon K author Ambert-Balay, Katia author Andrés, Cristina author Antón, Andrés author Auvray, Christelle author Bailly, Jean-Luc author Baldanti, Fausto author Bastings, Capser author Beard, Stuart author Berengua, Carla author Berginc, Natasa author Bloemen, Mandy author Blomqvist, Soile author Bosma, Froukje author Böttcher, Sindy author Bubba, Laura author Buderus, Stafan author Cabrerizo, Maria author Calvo, Cristina author Celma, Cristina author Ceriotti, Ferruccio author Clark, Gemma author Costa, Inës author Coste-Burel, Marianne author Couderé, Karen author Cremer, Jeroen author Del Cuerpo Casas, Margarita author Daehne, Theo author de Beer, Jessica author de Ceano-Vivas, Maria author De Gascun, Cillian author de Rougemont, Alexis author Dean, Jonathan author Dembinski, Jennifer L author Diedrich, Sabine author Diez-Domingo, Javier author Dillner, Lena author Dorenberg, Dagny H author Ducancelle, Alexandra author Dudman, Susanne author Dyrdak, Robert author Eis-Huebinger, Anna-Maria author Falces-Romero, Iker author Farkas, Agnes author Feeney, Susan author Fernandez-Garcia, Maria Dolores author Flipse, Jacky author Franck, Kristina T author Galli, Cristina author Garrigue, Isabelle author Geeraedts, Felix author Georgieva, Irina author Giardina, Federica author Guiomar, Raquel author Hauzenberger, Elenor author Heikens, Esther author Henquell, Cécille author Hober, Didier author Hönemann, Mario author Howson-Wells, Hannah author Hruškar, Željka author Ikonen, Niina author Imbert, Berthemarie author Jansz, Arjan R author Jeannoël, Marion author Jiřincová, Helena author Josset, Laurence author Keeren, Kathrin author Kramer-Lindhout, Naomie author Krokstad, Sidsel author Lazrek, Mouna author Le Guillou-Guillemette, Hélène author Lefeuvre, Caroline author Lind, Andreas author Lunar, Maja M author Maier, Melanie author Marque-Juillet, Stéphanie author McClure, C Patrick author McKenna, James author Meijer, Adam author Menasalvas Ruiz, Ana author Mengual-Chuliá, Beatriz author Midgley, Sofie author Mirand, Audrey author Molenkamp, Richard author Montes, Milagrosa author Moreno-Docón, Antonio author Morley, Ursula author Murk, Jean-Luc author Navascués-Ortega, Ana author Nijhuis, Roel author Nikolaeva-Glomb, Lubomira author Nordbø, Svein A author Numanovic, Sanela author Oggioni, Massimo author Oñate Vergara, Eider author Pacaud, Jordi author Pacreau, Marie L author Panning, Marcus author Pariani, Elena author Pekova, Lili author Pellegrinelli, Laura author Petrovec, Miroslav author Pietsch, Corinna author Pilorge, Léa author Piñeiro, Luis author Piralla, Antonio author Poljak, Mario author Prochazka, Birgit author Rabella, Nuria author Rahamat-Langendoen, Janette C author Rainetova, Petra author Reynders, Marijke author Riezebos-Brilman, Annelies author Roorda, Lieuwe author Savolainen-Kopra, Carita author Schuffenecker, Isabelle author Smeets, Leo C author Stoyanova, Asya author Stefic, Karl author Swanink, Caroline author Tabain, Irena author Tjhie, Jeroen author Thouault, Luc author Tumiotto, Camille author Uceda Renteria, Sara author Uršič, Tina author Vallet, Sophie author Van Ranst, Marc author Van Wunnik, Peter author Verweij, Jaco J author Vila, Jorgina author Wintermans, Bas author Wollants, Elke author Wolthers, Katja C author Xavier López-Labrador, F author Fischer, Thea Kølsen author Harvala, Heli author Benschop, Kimberley SM funder Austrian Federal Ministry of Health (Austria) funder Ministry of Health (República Checa) funder Instituto de Salud Carlos III funder Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública) funder Santé Publique France funder Unión Europea. Comisión Europea. NextGenerationEU funder Ministry of Health Welfare and Sport (Países Bajos) funder National Institutes of Health (Estados Unidos) funder Slovenian Research Agency funder Swiss National Science Foundation 2025-03-12T13:24:53Z 2025-03-12T13:24:53Z 2024-10-16 Simoes MP, Hodcroft EB, Simmonds P, et al.. Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study. J Infect Dis. 2024 Oct 16;230(4):e917-e928. 10.1093/infdis/jiae154 1537-6613 0022-1899 The Journal of infectious diseases 38547499 https://hdl.handle.net/20.500.12105/26435 Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages. eng European Non-Polio Enterovirus Network (ENPEN) Acute flaccid myelitis (AFM) Enterovirus D68 (EV-D68) Nonpolio enterovirus (NPEV) Respiratory infection Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study research article 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 URL https://repisalud.isciii.es/bitstreams/7d9451b6-7efc-43e2-8693-f8a80d34b996/download File MD5 cc5bb6b7e92561048046bd68765e21c5 704839 application/pdf EpidemiologicalClinicalCharacterizationCommunity_2024.pdf URL https://repisalud.isciii.es/bitstreams/e537292f-c9fb-48de-9f0a-400f9ec69464/download File MD5 130d22bfe5ec970f853bd0631fc02fd2 878846 application/pdf Supplementary_EpidemiologicalClinicalCharacterizationCommunity_2024.pdf