2026-05-20T03:47:34Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/264282025-12-18T13:01:30Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16978

00925njm 22002777a 4500 dc Ryan, Pablo author Valencia, Jorge author Cuevas, Guillermo author Amigot-Sánchez, Rafael author Martinez, Isidoro author Lazarus, Jeffrey V author Perez-Garcia, Felipe author Resino, Salvador author 2024-07 Background: People who use drugs (PWUD) are a key target population to reduce the burden of hepatitis C virus (HCV) infection. Aim: To assess risk factors and temporal trends of active HCV infection in PWUD in Madrid, Spain. Methods: We conducted a retrospective study between 2017 and 2023, including 2,264 PWUD visiting a mobile screening unit. Data about epidemiology, substance use and sexual risk behaviour were obtained through a 92-item questionnaire. HCV was detected by antibody test, followed by RNA test. The primary outcome variable was active HCV infection prevalence, calculated considering all individuals who underwent RNA testing and analysed by logistic regression adjusted by the main risk factors. Results: Of all participants, 685 tested positive for anti-HCV antibodies, and 605 underwent RNA testing; 314 had active HCV infection, and 218 initiated treatment. People who inject drugs (PWID) were identified as the main risk group. The active HCV infection rate showed a significant downward trend between 2017 and 2023 in the entire study population (23.4% to 6.0%), among PWID (41.0% to 15.0%) and PWUD without injecting drug use (7.0% to 1.3%) (p < 0.001 for all). These downward trends were confirmed by adjusted logistic regression for the entire study population (adjusted odds ratio (aOR): 0.78), PWID (aOR: 0.78), and PWUD non-IDU (aOR: 0.78). Conclusions: Our study demonstrates a significant reduction in active HCV infection prevalence among PWUD, particularly in PWID, which suggests that efforts in the prevention and treatment of HCV in Madrid, Spain, have had an impact on the control of HCV infection. Ryan P, Valencia J, Cuevas G, Amigot-Sanchez R, Martínez I, Lazarus JV, Pérez-García F, Resino S. Decrease in active hepatitis C infection among people who use drugs in Madrid, Spain, 2017 to 2023: a retrospective study. Euro Surveill. 2024 Jul;29(29):2300712. 10.2807/1560-7917.ES.2024.29.29.2300712 1560-7917 1025-496X Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin 39027941 https://hdl.handle.net/20.500.12105/26428 Hepatitis C Spain Epidemiology Mobile screening unit People who inject drugs People who use drugs Decrease in active hepatitis C infection among people who use drugs in Madrid, Spain, 2017 to 2023: a retrospective study