2026-07-21T11:10:01Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/264162025-12-18T13:00:21Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_19610col_20.500.12105_16981

00925njm 22002777a 4500 dc Sanz Olea, Enrique author Ojeda Sánchez, Carlos author Guxens, Mònica author Cañete, Adela author Pardo Romaguera, Elena author Gomez-Barroso, Diana author García-Pérez, Javier author Nuñez-Corcuera, Beatriz author Ortega-García, Juan Antonio author Ramis, Rebeca author 2024-06-24 Leukemia is the most common childhood cancer and its etiology could be related to various environmental contaminants such as particulate matter (PM). The objective of our study is to evaluate the potential association between exposure to PM during pregnancy and the incidence of childhood leukemia. We established a population-based nationwide cohort using the Spanish Birth Registry Statistics database of the National Statistics Institute. We used spatiotemporal land use random forest models to estimate the concentrations of PM10 and PM2.5 for the entire pregnancy and by trimesters. We conducted logistic regression analyses adjusted for various covariates. In addition, we fitted generalized additive models (GAMs) to estimate the non-linear relationship between PM levels and leukemia incidence. The study included 3,112,123 children and 1066 cases of leukemia. The results for the continuous variable of PM10 exposure levels suggested an increased risk of childhood leukemia to be associated with higher exposure. The results for the categorized PM10 variable suggest an increased risk of childhood leukemia among pregnant women whose exposure levels were higher than the median (third and fourth quartiles). The results for PM2.5 were weaker. We found association between exposure to PM10 during pregnancy and an increased risk of childhood leukemia. Our findings indicate that public health interventions should aim to reduce air pollution to lower the incidence of childhood leukemia. Sanz Olea, E.; Ojeda Sanchez, C.; Guxens, M.; Cañete, A.; Romaguera, E.P.; Gómez-Barroso, D.; García-Pérez, J.; Nuñez-Corcuera, B.; Ortega-García, J.A.; Ramis, R. Particulate Matter Exposure during Pregnancy and Childhood Leukemia Incidence. Atmosphere 2024, 15, 751. 10.3390/atmos15070751 2073-4433 Atmosphere https://hdl.handle.net/20.500.12105/26416 PM10 PM2.5 Environmental factors Childhood cancer Childhood leukemia Incidence Epidemiology Particulate Matter Exposure during Pregnancy and Childhood Leukemia Incidence