2026-06-14T03:39:13Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/264142025-12-18T13:00:38Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19612col_20.500.12105_19608col_20.500.12105_19613

00925njm 22002777a 4500 dc Imaz-Iglesia, Iñaki author Carmona, Montserrat author Garcia-Carpintero, Esther Elena author Pedrosa-Pérez, Lucía author Martínez-Portillo, Alejandro author Alcalde-Cabero, Enrique author Linertová, Renata author García-Pérez, Lidia author 2024-07-25 Two vaccines against rotavirus diseases, Rotarix® and RotaTeq®, are being marketed in Spain; but rotavirus is not presently among the diseases covered by universal vaccination in Spain. The aim of this study was to assess the efficiency of extending Spain's current targeted rotavirus vaccination strategy including only preterm babies, to a policy of universal vaccination. A de novo cohort-based Markov model was built to evaluate the efficiency of three compared rotavirus vaccination strategies in Spain: targeted, universal, and no vaccination. Using Rotarix® or RotaTeq®, we compared the cost-utility of these strategies from both a societal perspective and Spanish National Health System (SNHS) perspective. The model represents the most important clinical events conceivably linked to rotavirus infection. Efficacy, effectiveness, safety, costs, and utilities were identified by systematic reviews. Incremental cost-utility ratio (ICUR) is EUR 23,638/QALY (Quality-Adjusted Life Year) for targeted vaccination with Rotarix® compared with no vaccination. The ICUR for the rest of the strategies evaluated are above EUR 30,000/QALY. The sensitivity analysis shows price as the only parameter that could make the universal vaccination strategy efficient. Considering a threshold of EUR 25,000/QALY, only targeted vaccination with Rotarix® would be efficient from societal perspective. Price drops of 36.9% for Rotarix® and 44.6% for RotaTeq® would make universal vaccination efficient. Imaz-Iglesia I, Carmona M, García-Carpintero EE, Pedrosa-Pérez L, Martínez-Portillo A, Alcalde-Cabero E, Linertová R, García-Pérez L. Updating and Refining of Economic Evaluation of Rotavirus Vaccination in Spain: A Cost-Utility and Budget Impact Analysis. Viruses. 2024 Jul 25;16(8):1194. 10.3390/v16081194 1999-4915 Viruses 39205168 https://hdl.handle.net/20.500.12105/26414 Markov model Budget impact Cost-effectiveness Cost–utility Economic evaluation Rotavirus vaccine Updating and Refining of Economic Evaluation of Rotavirus Vaccination in Spain: A Cost-Utility and Budget Impact Analysis