2026-08-05T11:42:00Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/263962025-12-18T12:52:40Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19613col_20.500.12105_16977col_20.500.12105_16982

00925njm 22002777a 4500 dc Más-Fontao, Sebastián author Civantos, Esther author Boukichou-Abdelkader, Nisa author Moreno, Juan A author Tuomilehto, Jaakko author Gabriel-Sanchez, Rafael author Egido, Jesús author 2024-12-05 This sub-analysis of the ePREDICE trial, investigated the prevalence and determinants of renal complications, specifically glomerular hyperfiltration, albuminuria, and reduced kidney function, in individuals with prediabetes (PD). The cohort consisted of 967 participants from diverse backgrounds across seven countries. The kidney function was evaluated using the MDRD-4 equation, and the influence of various clinical and demographic factors on renal involvement was assessed by multivariable regression models. Additionally, insulinogenic and disposition indices were examined. Overall, the prevalence of renal abnormalities in this PD cohort was 9.2% (n = 89). Key findings included the detection of hyperfiltration in 20 (2%) individuals, albuminuria in 45 (4.7%), and CKD stage G3a in 29 (3%). Hyperfiltration was inversely correlated with age and height, while albuminuria showed a significant direct association with the disposition index (DI). Age and waist circumference were significantly and directly associated with estimated glomerular filtration rate (eGFR). The ePREDICE study highlights critical factors that affect renal involvement in PD individuals, revealing complex interactions among various parameters. These findings further emphasize the necessity for the search of early kidney abnormalities in people with PD especially in those in older age groups and with a large waist circumference. Mas-Fontao S, Civantos E, Boukichou N, Moreno JA, Tuomilehto J, Gabriel R, Egido J. Prevalence and factors linked to renal involvement in prediabetes patients across Europe in the ePREDICE trial. Sci Rep. 2024 Dec 5;14(1):30336. 10.1038/s41598-024-79842-w 2045-2322 Scientific reports 39638835 https://hdl.handle.net/20.500.12105/26396 Albuminuria Biomarkers Chronic kidney disease (CKD) Estimated glomerular filtration rate (eGFR) Prediabetes Prevalence and factors linked to renal involvement in prediabetes patients across Europe in the ePREDICE trial