2026-06-14T03:46:25Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/263882025-12-18T12:59:06Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610
Repisalud author Tagne-Fotso, Romuald author Riou, Margaux author Saoudi, Abdessattar author Zeghnoun, Abdelkrim author Frederiksen, Hanne author Berman, Tamar author Montazeri, Parisa author Andersson, Anna-Maria author Rodriguez-Martin, Laura author Åkesson, Agneta author Berglund, Marika author Biot, Pierre author Castaño, Argelia author Charles, Marie-Aline author Cocco, Emmanuelle author Den Hond, Elly author Dewolf, Marie-Christine author Esteban-Lopez, Marta author Gilles, Liese author Govarts, Eva author Guignard, Cedric author Gutleb, Arno C author Hartmann, Christina author Kold Jensen, Tina author Koppen, Gudrun author Kosjek, Tina author Lambrechts, Nathalie author McEachan, Rosemary author Sakhi, Amrit K author Snoj Tratnik, Janja author Uhl, Maria author Urquiza, Jose author Vafeiadi, Marina author Van Nieuwenhuyse, An author Vrijheid, Martine author Weber, Till author Zaros, Cécile author Tarroja-Aulina, Elena author Knudsen, Lisbeth E author Covaci, Adrian author Barouki, Robert author Kolossa-Gehring, Marike author Schoeters, Greet author Denys, Sebastien author Fillol, Clémence author Rambaud, Loïc funder Unión Europea. Comisión Europea. H2020 funder Wellcome Trust funder Medical Research Council (Reino Unido) funder Economic and Social Research Council (Reino Unido) funder British Heart Foundation funder NIHR - Collaboration for Leadership in Applied Health Research and Care Yorkshire and Humber funder Unión Europea. Comisión Europea. 7 Programa Marco funder Department of Environment and Health (Bélgica) funder Instituto de Salud Carlos III funder Ministerio de Agricultura, Alimentación y Medio Ambiente (España) funder Slovenian Research Agency funder Luxembourg Institute of Science and Technology funder Danish Ministry of Environment and Food funder Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (Alemania) funder Ministère de la Santé (Francia) funder French National Agency of Research (Francia) funder Government of Catalonia (España) funder Ministry of Higher Education and Research (Francia) funder Federal Ministry of Agriculture, Forestry, Environment and Water Management (Austria) funder Austrian Federal Ministry of Health (Austria) funder Environment and Health Fund (Israel) funder Environment Agency Austria 2025-02-27T09:45:17Z 2025-02-27T09:45:17Z 2024-08 Tagne-Fotso R, Riou M, Saoudi A, Zeghnoun A, Frederiksen H, Berman T, Montazeri P, Andersson AM, Rodriguez-Martin L, Akesson A, Berglund M, Biot P, Castaño A, Charles MA, Cocco E, Den Hond E, Dewolf MC, Esteban-Lopez M, Gilles L, Govarts E, Guignard C, Gutleb AC, Hartmann C, Kold Jensen T, Koppen G, Kosjek T, Lambrechts N, McEachan R, Sakhi AK, Snoj Tratnik J, Uhl M, Urquiza J, Vafeiadi M, Van Nieuwenhuyse A, Vrijheid M, Weber T, Zaros C, Tarroja-Aulina E, Knudsen LE, Covaci A, Barouki R, Kolossa-Gehring M, Schoeters G, Denys S, Fillol C, Rambaud L. Exposure to bisphenol A in European women from 2007 to 2014 using human biomonitoring data - The European Joint Programme HBM4EU. Environ Int. 2024 Aug;190:108912. 10.1016/j.envint.2024.108912 1873-6750 0160-4120 Environment international 39116556 https://hdl.handle.net/20.500.12105/26388 Background: Bisphenol A (BPA; or 4,4'-isopropylidenediphenol) is an endocrine disrupting chemical. It was widely used in a variety of plastic-based manufactured products for several years. The European Food Safety Authority (EFSA) recently reduced the Tolerable Daily Intake (TDI) for BPA by 20,000 times due to concerns about immune-toxicity. Objective: We used human biomonitoring (HBM) data to investigate the general level of BPA exposure from 2007 to 2014 of European women aged 18-73 years (n = 4,226) and its determinants. Methods: Fifteen studies from 12 countries (Austria, Belgium, Denmark, France, Germany, Greece, Israel, Luxembourg, Slovenia, Spain, Sweden, and the United Kingdom) were included in the BPA Study protocol developed within the European Joint Programme HBM4EU. Seventy variables related to the BPA exposure were collected through a rigorous post-harmonization process. Linear mixed regression models were used to investigate the determinants of total urine BPA in the combined population. Results: Total BPA was quantified in 85-100 % of women in 14 out of 15 contributing studies. Only the Austrian PBAT study (Western Europe), which had a limit of quantification 2.5 to 25-fold higher than the other studies (LOQ=2.5 µg/L), found total BPA in less than 5 % of the urine samples analyzed. The geometric mean (GM) of total urine BPA ranged from 0.77 to 2.47 µg/L among the contributing studies. The lowest GM of total BPA was observed in France (Western Europe) from the ELFE subset (GM=0.77 µg/L (0.98 µg/g creatinine), n = 1741), and the highest levels were found in Belgium (Western Europe) and Greece (Southern Europe), from DEMOCOPHES (GM=2.47 µg/L (2.26 µg/g creatinine), n = 129) and HELIX-RHEA (GM=2.47 µg/L (2.44 µg/g creatinine), n = 194) subsets, respectively. One hundred percent of women in 14 out of 15 data collections in this study exceeded the health-based human biomonitoring guidance value for the general population (HBM-GVGenPop) of 0.0115 µg total BPA/L urine derived from the updated EFSA's BPA TDI. Variables related to the measurement of total urine BPA and those related to the main socio-demographic characteristics (age, height, weight, education, smoking status) were collected in almost all studies, while several variables related to BPA exposure factors were not gathered in most of the original studies (consumption of beverages contained in plastic bottles, consumption of canned food or beverages, consumption of food in contact with plastic packaging, use of plastic film or plastic containers for food, having a plastic floor covering in the house, use of thermal paper…). No clear determinants of total urine BPA concentrations among European women were found. A broader range of data planned for collection in the original questionnaires of the contributing studies would have resulted in a more thorough investigation of the determinants of BPA exposure in European women. Conclusion: This study highlights the urgent need for action to further reduce exposure to BPA to protect the population, as is already the case in the European Union. The study also underscores the importance of pre-harmonizing HBM design and data for producing comparable data and interpretable results at a European-wide level, and to increase HBM uptake by regulatory agencies. eng Bisphenol A (BPA) Exposure determinants HBM4EU Human biomonitoring (HBM) Human exposure Questionnaire harmonization Standardized procedures Vulnerable population Exposure to bisphenol A in European women from 2007 to 2014 using human biomonitoring data - The European Joint Programme HBM4EU research article 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 URL https://repisalud.isciii.es/bitstreams/026cb85f-0c2c-4b3c-b5a0-771026a37a30/download File MD5 d89cfc4f790f6d76dd26b4c7cbd07360 4640284 application/pdf ExposureBisphenol_A_EuropeanWomen_2024.pdf URL https://repisalud.isciii.es/bitstreams/bf2c6082-98c4-4524-a8ca-e19186f92d48/download File MD5 a00afbbbf257ef2ed749ec5cc886332b 3241670 application/octet-stream Supplementary_Data_Exposure to bisphenol A in European women_2024.7z