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Repisalud author Diz-de Almeida, Silvia author Cruz, Raquel author Luchessi, Andre D author Lorenzo-Salazar, José M author López de Heredia, Miguel author Quintela, Inés author González-Montelongo, Rafaela author Nogueira Silbiger, Vivian author Porras, Marta Sevilla author Tenorio Castaño, Jair Antonio author Nevado, Julián author Aguado, José María author Aguilar, Carlos author Aguilera-Albesa, Sergio author Almadana, Virginia author Almoguera, Berta author Alvarez, Nuria author Andreu-Bernabeu, Álvaro author Arana-Arri, Eunate author Arango, Celso author Arranz, María J author Artiga, Maria-Jesus author Baptista-Rosas, Raúl C author Barreda-Sánchez, María author Belhassen-García, Moncef author Bezerra, Joao F author Bezerra, Marcos A C author Boix-Palop, Lucía author Brion, María author Brugada, Ramón author Bustos, Matilde author Calderón, Enrique J author Carbonell, Cristina author Castano, Luis author Castelao, Jose E author Conde-Vicente, Rosa author Cordero-Lorenzana, M Lourdes author Cortes-Sanchez, Jose L author Corton, Marta author Darnaude, M Teresa author De Martino-Rodríguez, Alba author Del Campo-Pérez, Victor author Diaz de Bustamante, Aranzazu author Domínguez-Garrido, Elena author Eirós, Rocío author Fariñas, María Carmen author Fernandez-Nestosa, María J author Fernández-Robelo, Uxía author Fernandez-Rodriguez, Amanda author Fernández-Villa, Tania author Gago-Dominguez, Manuela author Gil-Fournier, Belén author Gómez-Arrue, Javier author González Álvarez, Beatriz author González Bernaldo de Quirós, Fernan author González-Neira, Anna author González-Peñas, Javier author Gutiérrez-Bautista, Juan F author Herrero, María José author Herrero-Gonzalez, Antonio author Jimenez-Sousa, Maria Angeles author Lattig, María Claudia author Liger Borja, Anabel author Lopez-Rodriguez, Rosario author Mancebo, Esther author Martín-López, Caridad author Martín, Vicente author Martinez-Nieto, Oscar author Martinez-Lopez, Iciar author Martinez-Resendez, Michel F author Martinez-Perez, Angel author Mazzeu, Juliana F author Merayo Macías, Eleuterio author Minguez, Pablo author Moreno Cuerda, Victor author Oliveira, Silviene F author Ortega-Paino, Eva author Pompa-Mera, Ericka N author Parellada, Mara author Paz-Artal, Estela author Santos, Ney PC author Pérez-Matute, Patricia author Perez, Patricia author Pérez-Tomás, M Elena author Perucho, Teresa author Pinsach-Abuin, Mel·lina author Pita, Guillermo author Porras-Hurtado, Gloria L author Pujol, Aurora author Ramiro León, Soraya author Resino, Salvador author Fernandes, Marianne R author Rodríguez-Ruiz, Emilio author Rodríguez-Artalejo, Fernando author Rodriguez-Garcia, José A author Ruiz-Cabello, Francisco author Ruiz-Hornillos, Javier author Ryan, Pablo author Soria, José Manuel author Souto, Juan Carlos author Tamayo, Eduardo author Tamayo-Velasco, Álvaro author Taracido-Fernandez, Juan Carlos author Teper, Alejandro author Torres-Tobar, Lilian author Urioste, Miguel author Valencia-Ramos, Juan author Yáñez, Zuleima author Zarate, Ruth author de Rojas, Itziar author Ruiz, Agustín author Sánchez, Pascual author Real, Luis Miguel author SCOURGE Cohort Group author Guillén-Navarro, Encarna author Ayuso, Carmen author Parra, Esteban author Riancho, José A author Rojas-Martinez, Augusto author Flores, Carlos funder Instituto de Salud Carlos III funder Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) funder Banco Santander funder Fundación La Caixa funder Agencia Estatal de Investigación (España) funder Gobierno de Canarias (España) funder Fundación Canaria de Investigación Sanitaria funder Xunta de Galicia (España) funder Fundación Amancio Ortega funder Estrella de Levante funder Colabora Mujer 2025-02-21T12:46:21Z 2025-02-21T12:46:21Z 2024-10-03 Diz-de Almeida S, Cruz R, Luchessi AD, Lorenzo-Salazar JM, de Heredia ML, Quintela I, González-Montelongo R, Nogueira Silbiger V, Porras MS, Tenorio Castaño JA, Nevado J, Aguado JM, Aguilar C, Aguilera-Albesa S, Almadana V, Almoguera B, Alvarez N, Andreu-Bernabeu Á, Arana-Arri E, Arango C, Arranz MJ, Artiga MJ, Baptista-Rosas RC, Barreda-Sánchez M, Belhassen-Garcia M, Bezerra JF, Bezerra MAC, Boix-Palop L, Brion M, Brugada R, Bustos M, Calderón EJ, Carbonell C, Castano L, Castelao JE, Conde-Vicente R, Cordero-Lorenzana ML, Cortes-Sanchez JL, Corton M, Darnaude MT, De Martino-Rodríguez A, Del Campo-Pérez V, de Bustamante AD, Domínguez-Garrido E, Eirós R, Fariñas MC, Fernandez-Nestosa MJ, Fernández-Robelo U, Fernández-Rodríguez A, Fernández-Villa T, Gago-Dominguez M, Gil-Fournier B, Gómez-Arrue J, Álvarez BG, Bernaldo de Quirós FG, González-Neira A, González-Peñas J, Gutiérrez-Bautista JF, Herrero MJ, Herrero-Gonzalez A, Jimenez-Sousa MA, Lattig MC, Borja AL, Lopez-Rodriguez R, Mancebo E, Martín-López C, Martín V, Martinez-Nieto O, Martinez-Lopez I, Martinez-Resendez MF, Martinez-Perez A, Mazzeu JF, Macías EM, Minguez P, Cuerda VM, Oliveira SF, Ortega-Paino E, Parellada M, Paz-Artal E, Santos NPC, Pérez-Matute P, Perez P, Pérez-Tomás ME, Perucho T, Pinsach-Abuin M, Pita G, Pompa-Mera EN, Porras-Hurtado GL, Pujol A, León SR, Resino S, Fernandes MR, Rodríguez-Ruiz E, Rodriguez-Artalejo F, Rodriguez-Garcia JA, Ruiz-Cabello F, Ruiz-Hornillos J, Ryan P, Soria JM, Souto JC, Tamayo E, Tamayo-Velasco A, Taracido-Fernandez JC, Teper A, Torres-Tobar L, Urioste M, Valencia-Ramos J, Yáñez Z, Zarate R, de Rojas I, Ruiz A, Sánchez P, Real LM; SCOURGE Cohort Group; Guillen-Navarro E, Ayuso C, Parra E, Riancho JA, Rojas-Martinez A, Flores C, Lapunzina P, Carracedo Á. Novel risk loci for COVID-19 hospitalization among admixed American populations. Elife. 2024 Oct 3;13:RP93666. 10.7554/eLife.93666 2050-084X e-Life 39361370 https://hdl.handle.net/20.500.12105/26351 The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations ( and ). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in . Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research. spa COVID-19 GWAS SNP Genetics Genomics None Novel risk loci for COVID-19 hospitalization among admixed American populations research article 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 URL https://repisalud.isciii.es/bitstreams/3b0504a0-afd7-4307-9aa0-aa1a78da9b28/download File MD5 c03f4235f27876a1dd2fb8aea77a59c3 2820539 application/pdf NovelRiskLoci_COVID-19_Hospitalization_2024.pdf URL https://repisalud.isciii.es/bitstreams/7fbb6343-8490-4df9-b815-732896467d73/download File MD5 49ca6d575ee2497ec110280983d9e50b 3964294 application/pdf Figures_NovelRiskLoci_COVID-19_Hospitalization_2024.pdf URL https://repisalud.isciii.es/bitstreams/8f81c140-4260-4dbd-ac3a-78adb99ce54c/download File MD5 5bd3bf77efd46428268681ff6c0d3129 6159171 application/octet-stream Supplementary_NovelRiskLoci_COVID-19_Hospitalization_2024.7z