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00925njm 22002777a 4500 dc Diz-de Almeida, Silvia author Cruz, Raquel author Luchessi, Andre D author Lorenzo-Salazar, José M author López de Heredia, Miguel author Quintela, Inés author González-Montelongo, Rafaela author Nogueira Silbiger, Vivian author Porras, Marta Sevilla author Tenorio Castaño, Jair Antonio author Nevado, Julián author Aguado, José María author Aguilar, Carlos author Aguilera-Albesa, Sergio author Almadana, Virginia author Almoguera, Berta author Alvarez, Nuria author Andreu-Bernabeu, Álvaro author Arana-Arri, Eunate author Arango, Celso author Arranz, María J author Artiga, Maria-Jesus author Baptista-Rosas, Raúl C author Barreda-Sánchez, María author Belhassen-García, Moncef author Bezerra, Joao F author Bezerra, Marcos A C author Boix-Palop, Lucía author Brion, María author Brugada, Ramón author Bustos, Matilde author Calderón, Enrique J author Carbonell, Cristina author Castano, Luis author Castelao, Jose E author Conde-Vicente, Rosa author Cordero-Lorenzana, M Lourdes author Cortes-Sanchez, Jose L author Corton, Marta author Darnaude, M Teresa author De Martino-Rodríguez, Alba author Del Campo-Pérez, Victor author Diaz de Bustamante, Aranzazu author Domínguez-Garrido, Elena author Eirós, Rocío author Fariñas, María Carmen author Fernandez-Nestosa, María J author Fernández-Robelo, Uxía author Fernandez-Rodriguez, Amanda author Fernández-Villa, Tania author Gago-Dominguez, Manuela author Gil-Fournier, Belén author Gómez-Arrue, Javier author González Álvarez, Beatriz author González Bernaldo de Quirós, Fernan author González-Neira, Anna author González-Peñas, Javier author Gutiérrez-Bautista, Juan F author Herrero, María José author Herrero-Gonzalez, Antonio author Jimenez-Sousa, Maria Angeles author Lattig, María Claudia author Liger Borja, Anabel author Lopez-Rodriguez, Rosario author Mancebo, Esther author Martín-López, Caridad author Martín, Vicente author Martinez-Nieto, Oscar author Martinez-Lopez, Iciar author Martinez-Resendez, Michel F author Martinez-Perez, Angel author Mazzeu, Juliana F author Merayo Macías, Eleuterio author Minguez, Pablo author Moreno Cuerda, Victor author Oliveira, Silviene F author Ortega-Paino, Eva author Pompa-Mera, Ericka N author Parellada, Mara author Paz-Artal, Estela author Santos, Ney PC author Pérez-Matute, Patricia author Perez, Patricia author Pérez-Tomás, M Elena author Perucho, Teresa author Pinsach-Abuin, Mel·lina author Pita, Guillermo author Porras-Hurtado, Gloria L author Pujol, Aurora author Ramiro León, Soraya author Resino, Salvador author Fernandes, Marianne R author Rodríguez-Ruiz, Emilio author Rodríguez-Artalejo, Fernando author Rodriguez-Garcia, José A author Ruiz-Cabello, Francisco author Ruiz-Hornillos, Javier author Ryan, Pablo author Soria, José Manuel author Souto, Juan Carlos author Tamayo, Eduardo author Tamayo-Velasco, Álvaro author Taracido-Fernandez, Juan Carlos author Teper, Alejandro author Torres-Tobar, Lilian author Urioste, Miguel author Valencia-Ramos, Juan author Yáñez, Zuleima author Zarate, Ruth author de Rojas, Itziar author Ruiz, Agustín author Sánchez, Pascual author Real, Luis Miguel author SCOURGE Cohort Group author Guillén-Navarro, Encarna author Ayuso, Carmen author Parra, Esteban author Riancho, José A author Rojas-Martinez, Augusto author Flores, Carlos author 2024-10-03 The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations ( and ). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in . Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research. Diz-de Almeida S, Cruz R, Luchessi AD, Lorenzo-Salazar JM, de Heredia ML, Quintela I, González-Montelongo R, Nogueira Silbiger V, Porras MS, Tenorio Castaño JA, Nevado J, Aguado JM, Aguilar C, Aguilera-Albesa S, Almadana V, Almoguera B, Alvarez N, Andreu-Bernabeu Á, Arana-Arri E, Arango C, Arranz MJ, Artiga MJ, Baptista-Rosas RC, Barreda-Sánchez M, Belhassen-Garcia M, Bezerra JF, Bezerra MAC, Boix-Palop L, Brion M, Brugada R, Bustos M, Calderón EJ, Carbonell C, Castano L, Castelao JE, Conde-Vicente R, Cordero-Lorenzana ML, Cortes-Sanchez JL, Corton M, Darnaude MT, De Martino-Rodríguez A, Del Campo-Pérez V, de Bustamante AD, Domínguez-Garrido E, Eirós R, Fariñas MC, Fernandez-Nestosa MJ, Fernández-Robelo U, Fernández-Rodríguez A, Fernández-Villa T, Gago-Dominguez M, Gil-Fournier B, Gómez-Arrue J, Álvarez BG, Bernaldo de Quirós FG, González-Neira A, González-Peñas J, Gutiérrez-Bautista JF, Herrero MJ, Herrero-Gonzalez A, Jimenez-Sousa MA, Lattig MC, Borja AL, Lopez-Rodriguez R, Mancebo E, Martín-López C, Martín V, Martinez-Nieto O, Martinez-Lopez I, Martinez-Resendez MF, Martinez-Perez A, Mazzeu JF, Macías EM, Minguez P, Cuerda VM, Oliveira SF, Ortega-Paino E, Parellada M, Paz-Artal E, Santos NPC, Pérez-Matute P, Perez P, Pérez-Tomás ME, Perucho T, Pinsach-Abuin M, Pita G, Pompa-Mera EN, Porras-Hurtado GL, Pujol A, León SR, Resino S, Fernandes MR, Rodríguez-Ruiz E, Rodriguez-Artalejo F, Rodriguez-Garcia JA, Ruiz-Cabello F, Ruiz-Hornillos J, Ryan P, Soria JM, Souto JC, Tamayo E, Tamayo-Velasco A, Taracido-Fernandez JC, Teper A, Torres-Tobar L, Urioste M, Valencia-Ramos J, Yáñez Z, Zarate R, de Rojas I, Ruiz A, Sánchez P, Real LM; SCOURGE Cohort Group; Guillen-Navarro E, Ayuso C, Parra E, Riancho JA, Rojas-Martinez A, Flores C, Lapunzina P, Carracedo Á. Novel risk loci for COVID-19 hospitalization among admixed American populations. Elife. 2024 Oct 3;13:RP93666. 10.7554/eLife.93666 2050-084X e-Life 39361370 https://hdl.handle.net/20.500.12105/26351 COVID-19 GWAS SNP Genetics Genomics None Novel risk loci for COVID-19 hospitalization among admixed American populations