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oai:repisalud.isciii.es:20.500.12105/263402025-12-18T13:01:23Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16958col_20.500.12105_16963col_20.500.12105_16966col_20.500.12105_16975col_20.500.12105_16986col_20.500.12105_16988col_20.500.12105_16990col_20.500.12105_19617

00925njm 22002777a 4500 dc Mega Vascular Cognitive Impairment and Dementia (MEGAVCID) consortium author Calero, Miguel author 2024-09 Introduction: Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome-wide association studies (GWAS) focus on AD. Methods: We conducted a GWAS of all-cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors. Results: For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonance imaging markers of small vessel disease (SVD; HBEGF). Novel VaD loci were associated with hypertension, diabetes, and neuron maintenance (SPRY2, FOXA2, AJAP1, and PSMA3). Discussion: Our study identified genetic risks underlying ACD, demonstrating overlap with neurodegenerative processes, vascular risk factors, and cerebral SVD. Highlights: We conducted the largest genome-wide association study of all-cause dementia (ACD) and vascular dementia (VaD). Known genetic variants associated with AD were replicated for ACD and VaD. Functional analyses identified novel loci for ACD and VaD. Genetic risks of ACD overlapped with neurodegeneration, vascular risk factors, and cerebral small vessel disease. Mega Vascular Cognitive Impairment and Dementia (MEGAVCID) consortium. A genome-wide association meta-analysis of all-cause and vascular dementia. Alzheimers Dement. 2024 Sep;20(9):5973-5995. 10.1002/alz.14115 1552-5279 1552-5260 Alzheimer's & dementia : the journal of the Alzheimer's Association 39046104 https://hdl.handle.net/20.500.12105/26340 Alzheimer's disease GWAS meta‐analysis All‐cause dementia Cross‐ancestry Genome‐wide association study (GWAS) Vascular dementia A genome-wide association meta-analysis of all-cause and vascular dementia