2026-08-13T08:56:22Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/262652025-12-18T13:01:17Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610

00925njm 22002777a 4500 dc Namorado, Sónia author Martins, Carla author Ogura, Joana author Assunção, Ricardo author Vasco, Elsa author Appenzeller, Brice author Halldórsson, Thórhallur Ingi author Janasik, Beata author Kolossa-Gehring, Marike author Van Nieuwenhuyse, An author Ólafsdóttir, Kristin author Rambaud, Loïc author Riou, Margaux author Silva, Susana author Wasowicz, Wojciech author Weber, Till author Esteban-Lopez, Marta author Castaño, Argelia author Gilles, Liese author Rodriguez Martin, Laura author Govarts, Eva author Schoeters, Greet author Viegas, Susana author Silva, Maria João author Alvito, Paula author 2024-12 Mycotoxins are natural toxins produced by fungi that may cause adverse health effects thus constituting a public health concern. Deoxynivalenol (DON), a mycotoxin affecting the immune system and causing intestinal disorders, was selected as a priority under the European Human Biomonitoring Initiative (HBM4EU). Urinary total DON levels (tDON) of 1270 participants from six countries were used to characterize the internal exposure of the adult European population and identify the most relevant determinants of exposure. tDON concentrations' P50 and P95 were in the range of 0.41-10.16 µg/L (0.39-9.05 µg/g crt) and 3.25-46.58 µg/L (2.12-33.50 µg/g crt) respectively. Higher tDON levels were observed for (i) male participants from France and Germany, (ii) samples collected in spring and summer, (iii) participants with a lower educational level, (iv) participants living in rural areas, (v) individuals without a job in France and Luxembourg, while in Portugal higher exposure was observed in working individuals, (vi) individuals with higher consumption of cereals and bread. The proportion of individuals with exposure levels exceeding the HBM-GV of 23 µg/L was 12.3 %, ranging from 0.8 % to 20.7 % in the individual countries. This study on mycotoxins exposure has used post harmonized questionnaire data and validated analytical methodologies for analysis and covered countries representing the four geographical regions of Europe, having produced much needed knowledge on the exposure of the European adult population to deoxynivalenol. Namorado S, Martins C, Ogura J, Assunção R, Vasco E, Appenzeller B, I Halldorsson T, Janasik B, Kolossa-Gehring M, Van Nieuwenhuyse A, Ólafsdóttir K, Rambaud L, Riou M, Silva S, Wasowicz W, Weber T, Esteban-López M, Castaño A, Gilles L, Rodríguez Martin L, Govarts E, Schoeters G, Viegas S, Silva MJ, Alvito P. Exposure assessment of the European adult population to deoxynivalenol - Results from the HBM4EU Aligned Studies. Food Res Int. 2024 Dec;198:115281. 10.1016/j.foodres.2024.115281 1873-7145 0963-9969 Food research international 39643334 https://hdl.handle.net/20.500.12105/26265 Chemical exposure Deoxynivalenol HBM4EU Human biomonitoring Mycotoxins Risk assessment Exposure assessment of the European adult population to deoxynivalenol - Results from the HBM4EU Aligned Studies.