2026-05-23T05:24:38Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/262582025-12-18T13:00:38Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16973
Repisalud
author
Latorre-Millán, Miriam
author
Rodríguez Del Águila, María Mar
author
Clusa, Laura
author
Mazagatos, Clara
author
Larrauri, Amparo
author
Fernández, María Amelia
author
Rezusta, Antonio
author
Milagro, Ana María
funder
Unión Europea. Comisión Europea. H2020
2025-02-05T08:32:32Z
2025-02-05T08:32:32Z
2024-10-30
Latorre-Millán M, Rodríguez Del Águila MM, Clusa L, Mazagatos C, Larrauri A, Fernández MA, Rezusta A, Milagro AM. Severity Patterns in COVID-19 Hospitalised Patients in Spain: I-MOVE-COVID-19 Study. Viruses. 2024 Oct 30;16(11):1705.
10.3390/v16111705
1999-4915
Viruses
39599820
https://hdl.handle.net/20.500.12105/26258
In the frame of the I-MOVE-COVID-19 project, a cohort of 2050 patients admitted in two Spanish reference hospitals between March 2020 and December 2021 was selected and a range of clinical factor data were collected at admission to assess their impact on the risk COVID-19 severity outcomes through a multivariate adjusted analysis and nomograms. The need for ventilation and intensive care unit (ICU) admission were found to be directly associated with a higher death risk (OR 6.9 and 3.2, respectively). The clinical predictors of death were the need for ventilation and ICU, advanced age, neuromuscular disorders, thrombocytopenia, hypoalbuminemia, dementia, cancer, elevated creatin phosphokinase (CPK), and neutrophilia (OR between 1.8 and 3.5), whilst the presence of vomiting, sore throat, and cough diminished the risk of death (OR 0.5, 0.2, and 0.1, respectively). Admission to ICU was predicted by the need for ventilation, abdominal pain, and elevated lactate dehydrogenase (LDH) (OR 371.0, 3.6, and 2.2, respectively) as risk factors; otherwise, it was prevented by advanced age (OR 0.5). In turn, the need for ventilation was predicted by low oxygen saturation, elevated LDH and CPK, diabetes, neutrophilia, obesity, and elevated GGT (OR between 1.7 and 5.2), whilst it was prevented by hypertension (OR 0.5). These findings could enhance patient management and strategic interventions to combat COVID-19.
eng
COVID-19
ICU
SARS-CoV-2
Clinical phenotype
Death
Severity
Ventilation
Severity Patterns in COVID-19 Hospitalised Patients in Spain: I-MOVE-COVID-19 Study.
research article
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SeverityPatternsCOVID-19Hospitalised_2024.pdf
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Supplementary_SeverityPatternsCOVID-19Hospitalised_2024.pdf