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oai:repisalud.isciii.es:20.500.12105/262582025-12-18T13:00:38Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16973

00925njm 22002777a 4500 dc Latorre-Millán, Miriam author Rodríguez Del Águila, María Mar author Clusa, Laura author Mazagatos, Clara author Larrauri, Amparo author Fernández, María Amelia author Rezusta, Antonio author Milagro, Ana María author 2024-10-30 In the frame of the I-MOVE-COVID-19 project, a cohort of 2050 patients admitted in two Spanish reference hospitals between March 2020 and December 2021 was selected and a range of clinical factor data were collected at admission to assess their impact on the risk COVID-19 severity outcomes through a multivariate adjusted analysis and nomograms. The need for ventilation and intensive care unit (ICU) admission were found to be directly associated with a higher death risk (OR 6.9 and 3.2, respectively). The clinical predictors of death were the need for ventilation and ICU, advanced age, neuromuscular disorders, thrombocytopenia, hypoalbuminemia, dementia, cancer, elevated creatin phosphokinase (CPK), and neutrophilia (OR between 1.8 and 3.5), whilst the presence of vomiting, sore throat, and cough diminished the risk of death (OR 0.5, 0.2, and 0.1, respectively). Admission to ICU was predicted by the need for ventilation, abdominal pain, and elevated lactate dehydrogenase (LDH) (OR 371.0, 3.6, and 2.2, respectively) as risk factors; otherwise, it was prevented by advanced age (OR 0.5). In turn, the need for ventilation was predicted by low oxygen saturation, elevated LDH and CPK, diabetes, neutrophilia, obesity, and elevated GGT (OR between 1.7 and 5.2), whilst it was prevented by hypertension (OR 0.5). These findings could enhance patient management and strategic interventions to combat COVID-19. Latorre-Millán M, Rodríguez Del Águila MM, Clusa L, Mazagatos C, Larrauri A, Fernández MA, Rezusta A, Milagro AM. Severity Patterns in COVID-19 Hospitalised Patients in Spain: I-MOVE-COVID-19 Study. Viruses. 2024 Oct 30;16(11):1705. 10.3390/v16111705 1999-4915 Viruses 39599820 https://hdl.handle.net/20.500.12105/26258 COVID-19 ICU SARS-CoV-2 Clinical phenotype Death Severity Ventilation Severity Patterns in COVID-19 Hospitalised Patients in Spain: I-MOVE-COVID-19 Study.