2026-06-03T21:34:27Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/262552025-12-18T12:55:53Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16984
Repisalud
author
Domingo-Relloso, Arce
author
Riffo-Campos, Angela L
author
Zhao, Naisi
author
Ayala, Guillermo
author
Haack, Karin
author
Manterola, Carlos
author
Rhoades, Dorothy A
author
Umans, Jason G
author
Fallin, M Daniele
author
Herreros-Martinez, Miguel
author
Pollan-Santamaria, Marina
author
Boerwinkle, Eric
author
Platz, Elizabeth A
author
Jones, Miranda R
author
Bressler, Jan
author
Joehanes, Roby
author
Ryan, Calen P
author
Gonzalez, Juan R
author
Levy, Daniel
author
Belsky, Daniel W
author
Cole, Shelley A
author
Michaud, Dominique S
author
Tellez-Plaza, Maria
author
Navas-Acien, Ana
funder
NIH - National Heart, Lung, and Blood Institute (NHLBI) (Estados Unidos)
funder
NIH - National Institute of Environmental Health Sciences (NIEHS) (Estados Unidos)
funder
Instituto de Salud Carlos III
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Universidades (España)
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Fundación La Caixa
funder
United States Department of Health and Human Services
funder
NIH - National Cancer Institute (NCI) (Estados Unidos)
funder
Centers for Disease Control and Prevention (Estado Unidos)
funder
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2025-02-04T14:33:03Z
2025-02-04T14:33:03Z
2024-10
Domingo-Relloso A, Riffo-Campos AL, Zhao N, Ayala G, Haack K, Manterola C, Rhoades DA, Umans JG, Fallin MD, Herreros-Martinez M, Pollan M, Boerwinkle E, Platz EA, Jones MR, Bressler J, Joehanes R, Ryan CP, Gonzalez JR, Levy D, Belsky DW, Cole SA, Michaud DS, Navas-Acien A, Tellez-Plaza M. Multicohort Epigenome-Wide Association Study of All-Cause Cardiovascular Disease and Cancer Incidence: A Cardio-Oncology Approach. JACC CardioOncol. 2024 Sep 10;6(5):731-742.
10.1016/j.jaccao.2024.07.014
2666-0873
JACC. CardioOncology
39479324
https://hdl.handle.net/20.500.12105/26255
Background: Emerging evidence reveals a complex relationship between cardiovascular disease (CVD) and cancer, which share common risk factors and biological pathways. Objectives: The aim of this study was to evaluate common epigenetic signatures for CVD and cancer incidence in 3 ethnically diverse cohorts: Native Americans from the SHS (Strong Heart Study), European Americans from the FHS (Framingham Heart Study), and European Americans and African Americans from the ARIC (Atherosclerosis Risk In Communities) study. Methods: A 2-stage strategy was used that included first conducting untargeted epigenome-wide association studies for each cohort and then running targeted models in the union set of identified differentially methylated positions (DMPs). We also explored potential molecular pathways by conducting a bioinformatics analysis. Results: Common DMPs were identified across all populations. In a subsequent meta-analysis, 3 and 1 of those DMPs were statistically significant for CVD only and both cancer and CVD, respectively. No meta-analyzed DMPs were statistically significant for cancer only. The enrichment analysis pointed to interconnected biological pathways involved in cancer and CVD. In the DrugBank database, elements related to 1-carbon metabolism and cancer and CVD medications were identified as potential drugs for target gene products. In an additional analysis restricted to the 950 SHS participants who developed incident CVD, the C index for incident cancer increased from 0.618 (95% CI: 0.570-0.672) to 0.971 (95% CI: 0.963-0.978) when adjusting the models for the combined cancer and CVD DMPs identified in the other cohorts. Conclusions: These results point to molecular pathways and potential treatments for precision prevention of CVD and cancer. Screening based on common epigenetic signatures of incident CVD and cancer may help identify patients with newly diagnosed CVD at increased cancer risk.
eng
DNA methylation
Cancer
Cardio-oncology
Cardiovascular disease
Multicohort
Multicohort Epigenome-Wide Association Study of All-Cause Cardiovascular Disease and Cancer Incidence: A Cardio-Oncology Approach
research article
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MulticohortEpigenome-WideAssociation_2024.pdf
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Supplementary1_MulticohortEpigenome-WideAssociation_2024.pdf
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