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oai:repisalud.isciii.es:20.500.12105/262542025-12-18T13:01:26Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16959col_20.500.12105_16962col_20.500.12105_16968col_20.500.12105_16970col_20.500.12105_16974col_20.500.12105_16981col_20.500.12105_16983col_20.500.12105_16990

00925njm 22002777a 4500 dc Marcos-Delgado, Alba author Martín-Sánchez, Vicente author Molina-Barceló, Ana author Alonso-Molero, Jéssica author Perez-Gomez, Beatriz author Pollán, Marina author Aragones, Nuria author Ederra-Sanz, María author Fernández-Tardón, Guillermo author Binefa, Gemma author Moreno, Victor author Barrios-Rodríguez, Rocío author Amiano, Pilar author Huerta, José María author Teso, Enrique Pastor author Alguacil, Juan author Castaño-Vinyals, Gemma author Kogevinas, Manolis author Molina de la Torre, Antonio José author 2024-09-25 The aim of our study is to evaluate the relationship between sociodemographic and clinical characteristics of individuals with Colorectal Cancer (CRC), tumour-intrinsic characteristics and treatment received with health-related quality of life (HRQoL). Methods: Cross-sectional analysis of data from 805 survivors from the MCC study was conducted. HRQoL was assessed through a general and specific questionnaire, SF-12 and FCSI (Colorectal Symptom Index). Statistical analyses were performed with linear regression with adjustment for sociodemographic variables, stage at diagnosis and histological grade. Results: Participants had survived a median of 7.9 years from diagnosis (IQR 7.1-8.5 years). Age at diagnosis, sex and area showed a clear association with HRQoL in both physical and mental dimensions of the SF-12 questionnaire. A direct association between CRC recurrence was also found in the PCS-12 and MCS-12 dimensions and radical surgery in the PCS-12. Regarding the scores in FCSI questionnaire, statistically significant differences were observed by sex, age and area, with older women being the most impaired (p < 0.001). Conclusions: Age, sex and area was associated with lower scores of HRQoL among CRC survivors. Knowing the determinants related to HRQoL would allow us to lay the groundwork to develop strategies that help reduce morbidity and mortality, relapses and increase HRQoL. Marcos-Delgado A, Martín-Sánchez V, Molina-Barceló A, Alonso-Molero J, Pérez-Gómez B, Pollán M, Aragonés N, Ederra-Sanza M, Fernández-Tardón G, Binefa G, Moreno V, Barrios-Rodríguez R, Amiano P, Huerta JM, Teso EP, Alguacil J, Castaño-Vinyals G, Kogevinas M, Molina de la Torre AJ. Health-Related Quality of Life in Long-Term Colorectal Cancer Survivors. Healthcare (Basel). 2024 Sep 25;12(19):1917. 10.3390/healthcare12191917 2227-9032 Healthcare (Basel, Switzerland) 39408097 https://hdl.handle.net/20.500.12105/26254 Cancer survivors Colorectal cancer Health-related quality of life (HRQoL) Health-Related Quality of Life in Long-Term Colorectal Cancer Survivors