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oai:repisalud.isciii.es:20.500.12105/262362025-12-18T12:57:22Zcom_20.500.12105_2273com_20.500.12105_2202col_20.500.12105_19571

00925njm 22002777a 4500 dc Morales, Carmen author Losada, Ana author 2018-06 Replicated chromatids are held together from the time they emerge from the replication fork until their separation in anaphase. This process, known as cohesion, promotes faithful DNA repair by homologous recombination in interphase and ensures accurate chromosome segregation in mitosis. Identification of cohesin thirty years ago solved a long-standing question about the nature of the linkage keeping together the sister chromatids. Cohesin is an evolutionarily conserved complex composed of a heterodimer of the Structural Maintenance of Chromosomes (SMC) family of ATPases, Smc1 and Smc3, the kleisin subunit Rad21 and a Huntingtin/EF3/PP2A/Tor1 (HEAT) repeat domain-containing subunit named SA/STAG. In addition to mediating cohesion, cohesin plays a major role in genome organization. Cohesin functions rely on the ability of the complex to entrap DNA topologically and in a dynamic manner. Establishment of cohesion during S phase requires coordination with the DNA replication machinery and restricts the dynamic behaviour of at least a fraction of cohesin. Dissolution of cohesion in subsequent mitosis is regulated by multiple mechanisms that ensure that daughter cells receive the correct number of intact chromosomes. We here review recent progress on our understanding of how these processes are regulated in somatic vertebrate cells. Cancer Genet Cytogenet . 2004 Jan 1;148(1):35-43. Cancer Genet Cytogenet 29433064 https://hdl.handle.net/20.500.12105/26236 SISTER-CHROMATID COHESION CHROMOSOME BI-ORIENTATION DNA-REPLICATION AURORA B CENTROMERIC COHESION STRUCTURAL BASIS LOADER SCC2 ACETYLATION WAPL MITOSIS Establishing and dissolving cohesion during the vertebrate cell cycle.